C57BL/6NTac-Msx2tm1(EGFP/cre/ERT2)Wtsi/Cnrm

Status

Available to order

EMMA IDEM:09201
International strain nameC57BL/6NTac-Msx2tm1(EGFP/cre/ERT2)Wtsi/Cnrm
Alternative nameCEPD0038_1_D01
Strain type
Allele/Transgene symbolMsx2tm1(EGFP/cre/ERT2)Wtsi
Gene/Transgene symbolMsx2

Information from provider

Provider CNR, Consiglio Nazionale delle Ricerche
Provider affiliationEMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0038_1_D01. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • big ears / MGI
  • decreased bone mineral density / MGI
  • abnormal neurocranium morphology / MGI
  • abnormal frontal bone morphology / MGI
  • malocclusion / MGI
  • brittle teeth / MGI
  • degenerate molars / MGI
  • ameloblast degeneration / MGI
  • abnormal trabecular bone morphology / MGI
  • decreased compact bone thickness / MGI
  • abnormal long bone hypertrophic chondrocyte zone / MGI
  • decreased chondrocyte number / MGI
  • alopecia / MGI
  • delayed hair regrowth / MGI
  • abnormal nail morphology / MGI
  • deformed nails / MGI
  • long toenails / MGI
  • abnormal cerebellum development / MGI
  • cerebellum vermis hypoplasia / MGI
  • abnormal cerebellum anterior vermis morphology / MGI
  • absent cerebellum vermis lobule VIII / MGI
  • absent cerebellum vermis lobule IX / MGI
  • delaminated Purkinje cell layer / MGI
  • delaminated cerebellar granule layer / MGI
  • curly vibrissae / MGI
  • short vibrissae / MGI
  • abnormal eye development / MGI
  • abnormal lens vesicle development / MGI
  • microphthalmia / MGI
  • abnormal lens morphology / MGI
  • small lens / MGI
  • abnormal cornea morphology / MGI
  • corneal opacity / MGI
  • abnormal retina morphology / MGI
  • abnormal eye morphology / MGI
  • abnormal skeleton development / MGI
  • abnormal axial skeleton morphology / MGI
  • no abnormal phenotype detected / MGI
  • chondrodystrophy / MGI
  • short tibia / MGI
  • tonic seizures / MGI
  • short femur / MGI
  • abnormal optic vesicle formation / MGI
  • nervous system phenotype / MGI
  • embryonic growth retardation / MGI
  • abnormal mammary gland embryonic development / MGI
  • frontal bone foramen / MGI
  • small interparietal bone / MGI
  • small supraoccipital bone / MGI
  • decreased osteoclast cell number / MGI
  • premature hair loss / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • narrow eye opening / MGI
  • cardiovascular system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • vitreous body deposition / MGI
  • abnormal bone ossification / MGI
  • abnormal hair shedding / MGI
  • abnormal appendicular skeleton morphology / MGI
  • increased corneal stroma thickness / MGI
  • abnormal enamel organ morphology / MGI
  • mortality/aging / MGI
  • integument phenotype / MGI
  • anterior iris synechia / MGI
  • increased cornea thickness / MGI
  • long nails / MGI
  • abnormal nail matrix morphology / MGI
  • iris hyperplasia / MGI
  • decreased corneal epithelium thickness / MGI
  • abnormal stellate reticulum morphology / MGI
  • abnormal stratum intermedium morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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