MGI phenotypes (allele matching)
C3H;C-Atp2b2Tmy/H
| Status | Available to order |
| EMMA ID | EM:00092 |
| Citation information | RRID:IMSR_EM:00092 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3H;C-Atp2b2Tmy/H |
| Alternative name | GENA300 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Atp2b2Tmy |
| Gene/Transgene symbol | Atp2b2 |
Information from provider
| Provider | Nick Parkinson |
| Provider affiliation | MRC Mammalian Genetics Unit |
| Phenotypic information | These mice have late onset deafness. Heterozygotes are deaf at 140 days post partum. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal inner ear morphology / MGI
- cochlear degeneration / MGI
- abnormal inner ear vestibule morphology / MGI
- abnormal organ of Corti morphology / MGI
- organ of Corti degeneration / MGI
- abnormal cell death / MGI
- tremors / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal cerebellum morphology / MGI
- small cerebellum / MGI
- increased Purkinje cell number / MGI
- thin cerebellar molecular layer / MGI
- decreased body weight / MGI
- decreased body size / MGI
- ataxia / MGI
- circling / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- stereotypic behavior / MGI
- head bobbing / MGI
- decreased startle reflex / MGI
- abnormal posture / MGI
- limb grasping / MGI
- abnormal motor coordination/balance / MGI
- impaired swimming / MGI
- impaired righting response / MGI
- impaired limb coordination / MGI
- impaired balance / MGI
- infertility / MGI
- abnormal reflex / MGI
- abnormal hearing physiology / MGI
- deafness / MGI
- abnormal cochlear ganglion morphology / MGI
- cochlear ganglion degeneration / MGI
- absent otoliths / MGI
- abnormal postural reflex / MGI
- no phenotypic analysis / MGI
- absent tunnel of Corti / MGI
- abnormal Purkinje cell innervation / MGI
- abnormal cerebellar granule cell morphology / MGI
- abnormal calcium ion homeostasis / MGI
- absent organ of Corti supporting cells / MGI
- absent pillar cells / MGI
- absent vestibular hair cells / MGI
- vestibular saccular degeneration / MGI
- cochlear hair cell degeneration / MGI
- cochlear inner hair cell degeneration / MGI
- cochlear outer hair cell degeneration / MGI
- absent cochlear hair cells / MGI
- decreased cochlear hair cell number / MGI
- abnormal cochlear microphonics / MGI
- abnormal cochlear nerve compound action potential / MGI
- abnormal hair cell mechanoelectric transduction / MGI
- abnormal cochlear hair cell physiology / MGI
- abnormal vestibular hair cell physiology / MGI
- decreased organ of Corti supporting cell number / MGI
- abnormal cochlear hair cell stereociliary bundle morphology / MGI
- abnormal outer hair cell stereociliary bundle morphology / MGI
- absent outer hair cell stereocilia / MGI
- pillar cell degeneration / MGI
- increased susceptibility to noise-induced hearing loss / MGI
- abnormal auditory cortex morphology / MGI
- abnormal cochlear nerve morphology / MGI
- abnormal distortion product otoacoustic emission / MGI
- absent distortion product otoacoustic emissions / MGI
- abnormal auditory brainstem response / MGI
- sensorineural hearing loss / MGI
- abnormal vestibular system physiology / MGI
- increased susceptibility to age-related hearing loss / MGI
- syndromic hearing loss / MGI
- absent linear vestibular evoked potential / MGI
- reduced linear vestibular evoked potential / MGI
- lethargy / MGI
- head tossing / MGI
- hearing/vestibular/ear phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal vestibular saccule morphology / MGI
- impaired hearing / MGI
- absent pinna reflex / MGI
- abnormal Purkinje cell differentiation / MGI
- abnormal auditory brainstem response waveform shape / MGI
- increased or absent threshold for auditory brainstem response / MGI
- decreased threshold for auditory brainstem response / MGI
- abnormal cochlear VIII nucleus morphology / MGI
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191