MGI phenotypes (allele matching)
C3H;C-Atp2b2Tmy/H
| Status | Available to order |
| EMMA ID | EM:00092 |
| International strain name | C3H;C-Atp2b2Tmy/H |
| Alternative name | GENA300 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Atp2b2Tmy |
| Gene/Transgene symbol | Atp2b2 |
Information from provider
| Provider | Nick Parkinson |
| Provider affiliation | MRC Mammalian Genetics Unit |
| Phenotypic information | These mice have late onset deafness. Heterozygotes are deaf at 140 days post partum. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal inner ear morphology / MGI
- cochlear degeneration / MGI
- abnormal inner ear vestibule morphology / MGI
- abnormal organ of Corti morphology / MGI
- organ of Corti degeneration / MGI
- abnormal cell death / MGI
- tremors / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal cerebellum morphology / MGI
- small cerebellum / MGI
- increased Purkinje cell number / MGI
- thin cerebellar molecular layer / MGI
- decreased body weight / MGI
- decreased body size / MGI
- ataxia / MGI
- circling / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- stereotypic behavior / MGI
- head bobbing / MGI
- decreased startle reflex / MGI
- abnormal posture / MGI
- limb grasping / MGI
- abnormal motor coordination/balance / MGI
- impaired swimming / MGI
- impaired righting response / MGI
- impaired limb coordination / MGI
- impaired balance / MGI
- infertility / MGI
- abnormal reflex / MGI
- abnormal hearing physiology / MGI
- deafness / MGI
- abnormal cochlear ganglion morphology / MGI
- cochlear ganglion degeneration / MGI
- absent otoliths / MGI
- abnormal postural reflex / MGI
- no phenotypic analysis / MGI
- absent tunnel of Corti / MGI
- abnormal Purkinje cell innervation / MGI
- abnormal cerebellar granule cell morphology / MGI
- abnormal calcium ion homeostasis / MGI
- absent organ of Corti supporting cells / MGI
- absent pillar cells / MGI
- absent vestibular hair cells / MGI
- vestibular saccular degeneration / MGI
- cochlear hair cell degeneration / MGI
- cochlear inner hair cell degeneration / MGI
- cochlear outer hair cell degeneration / MGI
- absent cochlear hair cells / MGI
- decreased cochlear hair cell number / MGI
- abnormal cochlear microphonics / MGI
- abnormal cochlear nerve compound action potential / MGI
- abnormal hair cell mechanoelectric transduction / MGI
- abnormal cochlear hair cell physiology / MGI
- abnormal vestibular hair cell physiology / MGI
- decreased organ of Corti supporting cell number / MGI
- abnormal cochlear hair cell stereociliary bundle morphology / MGI
- abnormal outer hair cell stereociliary bundle morphology / MGI
- absent outer hair cell stereocilia / MGI
- pillar cell degeneration / MGI
- increased susceptibility to noise-induced hearing loss / MGI
- abnormal auditory cortex morphology / MGI
- abnormal cochlear nerve morphology / MGI
- abnormal distortion product otoacoustic emission / MGI
- absent distortion product otoacoustic emissions / MGI
- abnormal auditory brainstem response / MGI
- sensorineural hearing loss / MGI
- abnormal vestibular system physiology / MGI
- increased susceptibility to age-related hearing loss / MGI
- syndromic hearing loss / MGI
- absent linear vestibular evoked potential / MGI
- reduced linear vestibular evoked potential / MGI
- lethargy / MGI
- head tossing / MGI
- hearing/vestibular/ear phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal vestibular saccule morphology / MGI
- impaired hearing / MGI
- absent pinna reflex / MGI
- abnormal Purkinje cell differentiation / MGI
- abnormal auditory brainstem response waveform shape / MGI
- increased or absent threshold for auditory brainstem response / MGI
- decreased threshold for auditory brainstem response / MGI
- abnormal cochlear VIII nucleus morphology / MGI
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191