B6D2-Tg(KRT5-IKBKB)1Armz/Cnbc

Status	Available to order
EMMA ID	EM:09179
International strain name	B6D2-Tg(KRT5-IKBKB)1Armz/Cnbc
Alternative name	B6D2-Tg(krt5-hIKK2)1Armz
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(KRT5-IKBKB)1Armz
Gene/Transgene symbol	Tg(KRT5-IKBKB)1Armz

Information from provider

Provider	Angel Ramirez
Provider affiliation	Molecular Oncology Unit, Ciemat
Additional owner	Dr. A. Page. Molecular Oncology Unit. CIEMAT. Spain
Genetic information	Transgenic line expressing human IKK2 protein under the regulatory control of elements derived from the bovine Krt5 gene.
Phenotypic information	Homozygous: Unknown Heterozygous: Hemizygous mice have inflammation of oral epithelia (palate and forestomach). Some of the animals (10% - 20%) show squamous cell carcinoma in any of these epithelia that do not progress with age.
Breeding history	The line has been maintained by crossing the original founder (B6D2F2 background) to B6D2F1 hybrids, for more than 10 generations.
References	IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice.;Page Angustias, Bravo Ana, Suarez-Cabrera Cristian, Sanchez-Baltasar Raquel, Oteo Marta, Morcillo Miguel Angel, Casanova M Llanos, Segovia Jose C, Navarro Manuel, Ramirez Angel, ;2020;International journal of oral science;12;1; 31900382 IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf-Dependent.;Page Angustias, Bravo Ana, Suarez-Cabrera Cristian, Alameda Josefa P, Casanova M Llanos, Lorz Corina, Segrelles Carmen, Segovia José C, Paramio Jesús M, Navarro Manuel, Ramirez Angel, ;2017;Molecular cancer research : MCR;15;1255-1264; 28584022
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

MGI allele-associated human disease models

dermatitis / DOID:2723

Literature references

IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice.;Page Angustias, Bravo Ana, Suarez-Cabrera Cristian, Sanchez-Baltasar Raquel, Oteo Marta, Morcillo Miguel Angel, Casanova M Llanos, Segovia Jose C, Navarro Manuel, Ramirez Angel, ;2020;International journal of oral science;12;1; 31900382
IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf-Dependent.;Page Angustias, Bravo Ana, Suarez-Cabrera Cristian, Alameda Josefa P, Casanova M Llanos, Lorz Corina, Segrelles Carmen, Segovia José C, Paramio Jesús M, Navarro Manuel, Ramirez Angel, ;2017;Molecular cancer research : MCR;15;1255-1264; 28584022

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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