B6D2-Tg(KRT5-IKBKB)1Armz/Cnbc
| Status | Available to order |
| EMMA ID | EM:09179 |
| Citation information | RRID:IMSR_EM:09179 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6D2-Tg(KRT5-IKBKB)1Armz/Cnbc |
| Alternative name | B6D2-Tg(krt5-hIKK2)1Armz |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT5-IKBKB)1Armz |
| Gene/Transgene symbol | Tg(KRT5-IKBKB)1Armz |
Information from provider
| Provider | Angel Ramirez |
| Provider affiliation | Molecular Oncology Unit, Ciemat |
| Additional owner | Dr. A. Page. Molecular Oncology Unit. CIEMAT. Spain |
| Genetic information | Transgenic line expressing human IKK2 protein under the regulatory control of elements derived from the bovine Krt5 gene. |
| Phenotypic information | Homozygous:UnknownHeterozygous:Hemizygous mice have inflammation of oral epithelia (palate and forestomach). Some of the animals (10% - 20%) show squamous cell carcinoma in any of these epithelia that do not progress with age. |
| Breeding history | The line has been maintained by crossing the original founder (B6D2F2 background) to B6D2F1 hybrids, for more than 10 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice.;Page Angustias, Bravo Ana, Suarez-Cabrera Cristian, Sanchez-Baltasar Raquel, Oteo Marta, Morcillo Miguel Angel, Casanova M Llanos, Segovia Jose C, Navarro Manuel, Ramirez Angel, ;2020;International journal of oral science;12;1; 31900382
- IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf-Dependent.;Page Angustias, Bravo Ana, Suarez-Cabrera Cristian, Alameda Josefa P, Casanova M Llanos, Lorz Corina, Segrelles Carmen, Segovia José C, Paramio Jesús M, Navarro Manuel, Ramirez Angel, ;2017;Molecular cancer research : MCR;15;1255-1264; 28584022