B6.Cg-Tg(KRT5-cre)5132Jlj/Cnbc
| Status | Available to order |
| EMMA ID | EM:09178 |
| Citation information | RRID:IMSR_EM:09178 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(KRT5-cre)5132Jlj/Cnbc |
| Alternative name | B6J-Tg(krt5-Cre)1Armz |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT5-cre)5132Jlj |
| Gene/Transgene symbol | Tg(KRT5-cre)5132Jlj |
Information from provider
| Provider | Angel Ramirez |
| Provider affiliation | Molecular Oncology Unit, CIEMAT |
| Additional owner | José L. Jorcano. Head of the Division of Biomedicine, CIEMAT. Spain |
| Genetic information | Transgenic mice line with a Cre transgene regulated by regulatory elements derived from bovine keratin Krt5 gene. |
| Phenotypic information | Homozygous:Homozygous mice have not been generated.Heterozygous:Hemizygous mice do not show any obvious phenotype. |
| Breeding history | Backcrosses of transgenic mice from the original background (B6D2F2) to C57BL/6 background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Literature references
- A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination.;Ramirez Angel, Page Angustias, Gandarillas Alberto, Zanet Jennifer, Pibre Sophie, Vidal Miguel, Tusell Laura, Genesca Anna, Whitaker Duncan A, Melton David W, Jorcano Jose L, ;2004;Genesis (New York, N.Y. : 2000);39;52-7; 15124227
- Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes.;Brakebusch C, Grose R, Quondamatteo F, Ramirez A, Jorcano J L, Pirro A, Svensson M, Herken R, Sasaki T, Timpl R, Werner S, Fässler R, ;2000;The EMBO journal;19;3990-4003; 10921880
- Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis.;Sterneck E, Zhu S, Ramirez A, Jorcano J L, Smart R C, ;2006;Oncogene;25;1272-1276; 16205634
- Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues.;Berton Thomas R, Matsumoto Takashi, Page Angustias, Conti Claudio J, Deng Chu-Xia, Jorcano José L, Johnson David G, ;2003;Oncogene;22;5415-26; 12934101