MGI phenotypes (gene matching)
STOCK Samd8tm2.1Kwi/Cnrm
| Status | Available to order |
| EMMA ID | EM:09173 |
| Citation information | RRID:IMSR_EM:09173 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Samd8tm2.1Kwi/Cnrm |
| Alternative name | B6N;129P2-SMSrtm11Kwi/Cnrm |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Samd8tm2.1Kwi |
| Gene/Transgene symbol | Samd8 |
Information from provider
| Provider | Klaus Willecke |
| Provider affiliation | Molecular Genetics, Limes Institute |
| Genetic information | Smsr (Samd8) flox: catalytically active exon 6 is floxed; cre recombinase-mediated recombination leads to production of Smsr protein lacking carboxy-terminus; cre-mediated recombination leads to the production of a catalytically inactive Smsr-eGFP fusion protein. |
| Phenotypic information | Homozygous:Fertile with no obvious phenotypic abnormalitiesHeterozygous:Fertile with no obvious phenotypic abnormalities |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis.;Tafesse Fikadu G, Vacaru Ana M, Bosma Elleke F, Hermansson Martin, Jain Amrita, Hilderink Angelika, Somerharju Pentti, Holthuis Joost C M, ;2014;Journal of cell science;127;445-54; 24259670
- Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER.;Vacaru Ana M, Tafesse Fikadu G, Ternes Philipp, Kondylis Vangelis, Hermansson Martin, Brouwers Jos F H M, Somerharju Pentti, Rabouille Catherine, Holthuis Joost C M, ;2009;The Journal of cell biology;185;1013-27; 19506037