C57BL/6NTac-Ift140tm1a(KOMP)Wtsi/WtsiPh

Status

Available to order

EMMA IDEM:09158
Citation informationRRID:IMSR_EM:09158 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Ift140tm1a(KOMP)Wtsi/WtsiPh
Alternative nameEPD0073_5_B02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolIft140tm1a(KOMP)Wtsi
Gene/Transgene symbolIft140
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0073_5_B02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • absent neurocranium / MGI
  • abnormal exoccipital bone morphology / MGI
  • cleft palate / MGI
  • abnormal rib morphology / MGI
  • rib bifurcation / MGI
  • abnormal heart looping / MGI
  • abnormal interventricular septum morphology / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal mouth morphology / MGI
  • abnormal maxilla morphology / MGI
  • maxilla hypoplasia / MGI
  • polydactyly / MGI
  • oligodactyly / MGI
  • absent spleen / MGI
  • exencephaly / MGI
  • abnormal lung morphology / MGI
  • anophthalmia / MGI
  • abnormal somite development / MGI
  • abnormal digit morphology / MGI
  • abnormal neural tube morphology / MGI
  • hydrops fetalis / MGI
  • abnormal tricuspid valve morphology / MGI
  • persistent truncus arteriosis / MGI
  • abnormal atrioventricular valve morphology / MGI
  • curly tail / MGI
  • omphalocele / MGI
  • spina bifida / MGI
  • absent tympanic ring / MGI
  • left pulmonary isomerism / MGI
  • kidney cysts / MGI
  • abnormal neural tube closure / MGI
  • abnormal aortic arch morphology / MGI
  • right aortic arch / MGI
  • absent alisphenoid bone / MGI
  • absent palatine bone / MGI
  • cervical vertebral fusion / MGI
  • premaxilla hypoplasia / MGI
  • abnormal heart ventricle morphology / MGI
  • abnormal limb bud morphology / MGI
  • abnormal costovertebral joint morphology / MGI
  • heart hemorrhage / MGI
  • exostosis / MGI
  • palatal shelf hypoplasia / MGI
  • atrioventricular septal defect / MGI
  • fusion of atlas and occipital bones / MGI
  • prenatal growth retardation / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • abnormal hindlimb bud morphology / MGI
  • abnormal primary cilium morphology / MGI
  • absent facial bone / MGI
  • facial bone hypoplasia / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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