C3H.C-Mecom^Jbo/H

MGI allele-associated human disease models

• otitis media / DOID:10754

Orphanet associated rare diseases, based on orthologous gene matching

• Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome / Orphanet_71289

• A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
• Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media.;Parkinson Nicholas, Hardisty-Hughes Rachel E, Tateossian Hilda, Tsai Hsun-Tien, Brooker Debra, Morse Sue, Lalane Zuzanna, MacKenzie Francesca, Fray Martin, Glenister Pete, Woodward Anne-Marie, Polley Sian, Barbaric Ivana, Dear Neil, Hough Tertius A, Hunter A Jackie, Cheeseman Michael T, Brown Steve D M, ;2006;PLoS genetics;2;e149; 17029558
• Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.;Del-Pozo Jorge, MacIntyre Neil, Azar Ali, Glover James, Milne Elspeth, Cheeseman Michael, ;2019;Disease models & mechanisms;12;3564-3577; 30898767
• The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa.;Del-Pozo Jorge, Headon Denis J, Glover James D, Azar Ali, Schuepbach-Mallepell Sonia, Bhutta Mahmood F, Riddell Jon, Maxwell Scott, Milne Elspeth, Schneider Pascal, Cheeseman Michael, ;2022;Disease models & mechanisms;15;985214; 35107126
• Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology.;Azar Ali, Piccinelli Chiara, Brown Helen, Headon Denis, Cheeseman Michael, ;2016;Human molecular genetics;25;95-112.e18; 27378689
• Trans-cortical vessels in the mouse temporal bulla bone are a means to recruit myeloid cells in chronic otitis media and limit peripheral leukogram changes.;Azar Ali, Bhutta Mahmood F, Del-Pozo Jorge, Milne Elspeth, Cheeseman Michael, ;2022;Frontiers in genetics;13;69-79; 36246635
• Limb development genes underlie variation in human fingerprint patterns.;Li Jinxi, Glover James D, Zhang Haiguo, Peng Meifang, Tan Jingze, Mallick Chandana Basu, Hou Dan, Yang Yajun, Wu Sijie, Liu Yu, Peng Qianqian, Zheng Shijie C, Crosse Edie I, Medvinsky Alexander, Anderson Richard A, Brown Helen, Yuan Ziyu, Zhou Shen, Xu Yanqing, Kemp John P, Ho Yvonne Y W, Loesch Danuta Z, Wang Lizhong, Li Yingxiang, Tang Senwei, Wu Xiaoli, Walters Robin G, Lin Kuang, Meng Ruogu, Lv Jun, Chernus Jonathan M, Neiswanger Katherine, Feingold Eleanor, Evans David M, Medland Sarah E, Martin Nicholas G, Weinberg Seth M, Marazita Mary L, Chen Gang, Chen Zhengming, Zhou Yong, Cheeseman Michael, Wang Lan, Jin Li, Headon Denis J, Wang Sijia, ;2022;Cell;185;29-46; 34995520
• A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse.;Hood Derek, Moxon Richard, Purnell Tom, Richter Caroline, Williams Debbie, Azar Ali, Crompton Michael, Wells Sara, Fray Martin, Brown Steve D M, Cheeseman Michael T, ;2016;Disease models & mechanisms;9;; 26611891
• Non-Typeable Haemophilus influenzae Infection of the Junbo Mouse.;Cheeseman Michael T, Hood Derek W, ;2017;Current protocols in mouse biology;7;; 28252201