C57BL/6N-Mocs2tm1b(EUCOMM)Wtsi/Ieg

Status

Available to order

EMMA IDEM:09099
International strain nameC57BL/6N-Mocs2tm1b(EUCOMM)Wtsi/Ieg
Alternative nameEPD0560_5_C09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolMocs2tm1b(EUCOMM)Wtsi
Gene/Transgene symbolMocs2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0560_5_C09. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sor). Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration.;Karampelias Christos, Băloiu Bianca, Rathkolb Birgit, da Silva-Buttkus Patricia, Bachar-Wikström Etty, Marschall Susan, Fuchs Helmut, Gailus-Durner Valerie, Chu Lianhe, Hrabě de Angelis Martin, Andersson Olov, ;2024;Life science alliance;7;; 39159974

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6NTac, wild-type C57BL/6NTac
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Sulfite oxidase deficiency due to molybdenum cofactor deficiency type B / Orphanet_308393
IMPC phenotypes (allele matching)
  • decreased body length / IMPC
  • persistence of hyaloid vascular system / IMPC
  • decreased circulating sodium level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased fasting circulating glucose level / IMPC
IMPC phenotypes (gene matching)
  • decreased circulating sodium level / IMPC
  • increased fasting circulating glucose level / IMPC
  • decreased body length / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • persistence of hyaloid vascular system / IMPC
MGI phenotypes (gene matching)
  • hemoglobinuria / MGI
  • weakness / MGI
  • muscle weakness / MGI
  • flaky skin / MGI
  • wrinkled skin / MGI
  • decreased body size / MGI
  • curly vibrissae / MGI
  • postnatal growth retardation / MGI
  • abnormal hair growth / MGI
  • abnormal vibrissa morphology / MGI
  • nephrolithiasis / MGI
  • increased urine protein level / MGI
  • increased neuron apoptosis / MGI
  • kidney failure / MGI
  • ischuria / MGI
  • abnormal kidney pelvis morphology / MGI
  • abnormal kidney collecting duct morphology / MGI
  • increased circulating creatinine level / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • slow postnatal weight gain / MGI
  • decreased blood uric acid level / MGI
  • urinary bladder obstruction / MGI
  • abnormal blood homeostasis / MGI
  • abnormal urine homeostasis / MGI
  • postnatal lethality, complete penetrance / MGI
  • erythrocyturia / MGI
  • decreased urine uric acid level / MGI
  • cystolithiasis / MGI
  • cystinuria / MGI

Literature references

  • Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration.;Karampelias Christos, Băloiu Bianca, Rathkolb Birgit, da Silva-Buttkus Patricia, Bachar-Wikström Etty, Marschall Susan, Fuchs Helmut, Gailus-Durner Valerie, Chu Lianhe, Hrabě de Angelis Martin, Andersson Olov, ;2024;Life science alliance;7;; 39159974

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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