C57BL/6N-Alkbh1tm1a(EUCOMM)Hmgu/Ieg

Status

Available to order

EMMA IDEM:09068
International strain nameC57BL/6N-Alkbh1tm1a(EUCOMM)Hmgu/Ieg
Alternative nameHEPD0751_6_G08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAlkbh1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolAlkbh1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0751_6_G08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6NTacUSA, wild-type C57BL/6NTacUSA
Stage of embryos2-cell

Disease and phenotype information

IMPC phenotypes (gene matching)
  • enlarged lymph nodes / IMPC
  • abnormal ileum morphology / IMPC
  • abnormal mammary gland morphology / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased Ly6C-positive NK T cell number / IMPC
  • increased plasmacytoid dendritic cell number / IMPC
  • abnormal liver morphology / IMPC
  • abnormal spleen morphology / IMPC
  • abnormal kidney morphology / IMPC
MGI phenotypes (gene matching)
  • abnormal interparietal bone morphology / MGI
  • abnormal frontal bone morphology / MGI
  • abnormal parietal bone morphology / MGI
  • abnormal tooth development / MGI
  • abnormal sternum morphology / MGI
  • short snout / MGI
  • abnormal mandible morphology / MGI
  • exencephaly / MGI
  • small testis / MGI
  • seminiferous tubule degeneration / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • abnormal lens morphology / MGI
  • retinal degeneration / MGI
  • disorganized retinal layers / MGI
  • decreased trophoblast giant cell number / MGI
  • postnatal growth retardation / MGI
  • intracranial hemorrhage / MGI
  • decreased litter size / MGI
  • abnormal eye morphology / MGI
  • abnormal seminiferous tubule morphology / MGI
  • abnormal lens fiber morphology / MGI
  • abnormal metatarsal bone morphology / MGI
  • aphakia / MGI
  • delayed intramembranous bone ossification / MGI
  • abnormal neural tube closure / MGI
  • decreased fetal size / MGI
  • fetal growth retardation / MGI
  • pale placenta / MGI
  • short frontal bone / MGI
  • short nasal bone / MGI
  • absent nasal bone / MGI
  • decreased testis weight / MGI
  • decreased male germ cell number / MGI
  • decreased placenta weight / MGI
  • ectopia lentis / MGI
  • abnormal phalanx morphology / MGI
  • reproductive system phenotype / MGI
  • abnormal cell physiology / MGI
  • abnormal sternum ossification / MGI
  • decreased survivor rate / MGI
  • abnormal placenta junctional zone morphology / MGI
  • abnormal spongiotrophoblast cell morphology / MGI
  • decreased birth weight / MGI
  • delayed cranial suture closure / MGI
  • abnormal survival / MGI
  • decreased placental labyrinth size / MGI
  • acoria / MGI
  • decreased trophoblast glycogen cell number / MGI
  • decreased bone ossification / MGI
  • wide cranial sutures / MGI
  • broad snout / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).