- increased neutrophil cell number / IMPC
- decreased hemoglobin content / IMPC
- decreased circulating amylase level / IMPC
- increased large unstained cell number / IMPC
- increased kidney weight / IMPC
- decreased basophil cell number / IMPC
- irregularly shaped pupil / IMPC
- decreased lymphocyte cell number / IMPC
C57BL/6N-Col4a3tm1c(EUCOMM)Wtsi/H
Status | Available to order |
EMMA ID | EM:09043 |
International strain name | C57BL/6N-Col4a3tm1c(EUCOMM)Wtsi/H |
Alternative name | EPD0425_4_B07 |
Strain type | Targeted Mutant Strains : Targeted Conditional |
Allele/Transgene symbol | Col4a3tm1c(EUCOMM)Wtsi |
Gene/Transgene symbol | Col4a3 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mary Lyon Centre at MRC Harwell |
Genetic information | This line originates from EUCOMM ES clone EPD0425_4_B07, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant Alport syndrome / Orphanet_88918
- Autosomal recessive Alport syndrome / Orphanet_88919
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal membranous labyrinth morphology / MGI
- abnormal stria vascularis morphology / MGI
- decreased body weight / MGI
- abnormal lens morphology / MGI
- polyuria / MGI
- premature death / MGI
- abnormal kidney morphology / MGI
- glomerulonephritis / MGI
- albuminuria / MGI
- increased urine protein level / MGI
- small kidney / MGI
- renal interstitial fibrosis / MGI
- kidney failure / MGI
- abnormal strial marginal cell morphology / MGI
- abnormal stria vascularis vasculature morphology / MGI
- abnormal cochlear basement membrane morphology / MGI
- sensorineural hearing loss / MGI
- pale kidney / MGI
- kidney atrophy / MGI
- hematuria / MGI
- lethargy / MGI
- glomerulosclerosis / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal podocyte morphology / MGI
- decreased renal glomerular filtration rate / MGI
- increased circulating creatinine level / MGI
- increased blood urea nitrogen level / MGI
- abnormal podocyte foot process morphology / MGI
- podocyte foot process effacement / MGI
- decreased survivor rate / MGI
- uremia / MGI
- abnormal glomerular capillary morphology / MGI
- renal tubule atrophy / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- abnormal renal glomerulus basement membrane thickness / MGI
- expanded mesangial matrix / MGI
- renal glomerulus fibrosis / MGI
- renal cast / MGI
- increased renal glomerulus basement membrane thickness / MGI
- mesangial cell hyperplasia / MGI
- glomerulus hemorrhage / MGI
- glomerular crescent / MGI
- granular kidney / MGI
- podocyte microvillus transformation / MGI
- increased or absent threshold for auditory brainstem response / MGI
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