- increased neutrophil cell number / IMPC
- decreased hemoglobin content / IMPC
- decreased circulating amylase level / IMPC
- increased large unstained cell number / IMPC
- increased kidney weight / IMPC
- decreased basophil cell number / IMPC
- irregularly shaped pupil / IMPC
- decreased lymphocyte cell number / IMPC
C57BL/6N-Col4a3tm1c(EUCOMM)Wtsi/H
Status | Available to order |
EMMA ID | EM:09043 |
Citation information | RRID:IMSR_EM:09043 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6N-Col4a3tm1c(EUCOMM)Wtsi/H |
Alternative name | EPD0425_4_B07 |
Strain type | Targeted Mutant Strains : Targeted Conditional |
Allele/Transgene symbol | Col4a3tm1c(EUCOMM)Wtsi |
Gene/Transgene symbol | Col4a3 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mary Lyon Centre at MRC Harwell |
Genetic information | This line originates from EUCOMM ES clone EPD0425_4_B07, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant Alport syndrome / Orphanet_88918
- Autosomal recessive Alport syndrome / Orphanet_88919
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal membranous labyrinth morphology / MGI
- abnormal stria vascularis morphology / MGI
- decreased body weight / MGI
- abnormal lens morphology / MGI
- polyuria / MGI
- premature death / MGI
- abnormal kidney morphology / MGI
- glomerulonephritis / MGI
- albuminuria / MGI
- increased urine protein level / MGI
- small kidney / MGI
- renal interstitial fibrosis / MGI
- kidney failure / MGI
- abnormal strial marginal cell morphology / MGI
- abnormal stria vascularis vasculature morphology / MGI
- abnormal cochlear basement membrane morphology / MGI
- sensorineural hearing loss / MGI
- pale kidney / MGI
- kidney atrophy / MGI
- hematuria / MGI
- lethargy / MGI
- glomerulosclerosis / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal podocyte morphology / MGI
- decreased renal glomerular filtration rate / MGI
- increased circulating creatinine level / MGI
- increased blood urea nitrogen level / MGI
- abnormal podocyte foot process morphology / MGI
- podocyte foot process effacement / MGI
- decreased survivor rate / MGI
- uremia / MGI
- abnormal glomerular capillary morphology / MGI
- renal tubule atrophy / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- abnormal renal glomerulus basement membrane thickness / MGI
- expanded mesangial matrix / MGI
- renal glomerulus fibrosis / MGI
- renal cast / MGI
- increased renal glomerulus basement membrane thickness / MGI
- mesangial cell hyperplasia / MGI
- glomerulus hemorrhage / MGI
- glomerular crescent / MGI
- granular kidney / MGI
- podocyte microvillus transformation / MGI
- increased or absent threshold for auditory brainstem response / MGI
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