IMPC phenotypes (gene matching)
C57BL/6N-Lifrtm1c(EUCOMM)Hmgu/H
| Status | Available to order |
| EMMA ID | EM:09032 |
| Citation information | RRID:IMSR_EM:09032 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Lifrtm1c(EUCOMM)Hmgu/H |
| Alternative name | HEPD0662_5_B09 |
| Strain type | Targeted Mutant Strains : Targeted Conditional |
| Allele/Transgene symbol | Lifrtm1c(EUCOMM)Hmgu |
| Gene/Transgene symbol | Lifr |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This line originates from EUCOMM ES clone HEPD0662_5_B09, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Stüve-Wiedemann syndrome / Orphanet_3206
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal renal/urinary system morphology / MGI
- hydronephrosis / MGI
- abnormal kidney development / MGI
- abnormal ureter morphology / MGI
- hydroureter / MGI
- decreased motor neuron number / MGI
- abnormal dorsal root ganglion morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal placenta morphology / MGI
- abnormal kidney morphology / MGI
- abnormal astrocyte morphology / MGI
- cryptorchism / MGI
- small kidney / MGI
- abnormal metacarpal bone morphology / MGI
- renal hypoplasia / MGI
- abnormal long bone morphology / MGI
- decreased fetal size / MGI
- decreased renal glomerulus number / MGI
- increased osteoclast cell number / MGI
- increased liver glycogen level / MGI
- decreased bone volume / MGI
- neonatal lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality before implantation, incomplete penetrance / MGI
- decreased nephron number / MGI
- abnormal ureter smooth muscle morphology / MGI
- ectopic ureter / MGI
- blind ureter / MGI