IMPC phenotypes (allele matching)
C57BL/6N-Slc6a2tm1b(EUCOMM)Hmgu/Cnrm
| Status | Available to order |
| EMMA ID | EM:09028 |
| International strain name | C57BL/6N-Slc6a2tm1b(EUCOMM)Hmgu/Cnrm |
| Alternative name | HEPD0649_1_F02 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Slc6a2tm1b(EUCOMM)Hmgu |
| Gene/Transgene symbol | Slc6a2 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | CNR, Consiglio Nazionale delle Ricerche |
| Provider affiliation | EMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0649_1_F02. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sortm1(ACTB-cre,-EGFP)Ics (MGI:5285392)). Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Postural orthostatic tachycardia syndrome due to NET deficiency / Orphanet_443236
MGI phenotypes (gene matching)
- decreased body weight / MGI
- increased anxiety-related response / MGI
- hypoactivity / MGI
- increased dopamine level / MGI
- increased thermal nociceptive threshold / MGI
- increased chemically-elicited antinociception / MGI
- abnormal emotion/affect behavior / MGI
- behavioral despair / MGI
- increased heart rate / MGI
- decreased vertical activity / MGI
- increased thigmotaxis / MGI
- enhanced long term potentiation / MGI
- nervous system phenotype / MGI
- abnormal nervous system physiology / MGI
- abnormal noradrenaline level / MGI
- cardiovascular system phenotype / MGI
- decreased body temperature / MGI
- increased circulating adrenaline level / MGI
- increased circulating noradrenaline level / MGI
- abnormal physiological response to xenobiotic / MGI
- increased physiological sensitivity to xenobiotic / MGI
- impaired behavioral response to xenobiotic / MGI
- enhanced behavioral response to addictive substance / MGI
- enhanced behavioral response to cocaine / MGI
- impaired behavioral response to cocaine / MGI