C57BL/6-Tg(Itgax-cre/ERT)61Gkl/Flmg

Status	Available to order
EMMA ID	EM:09004
Citation information	RRID:IMSR_EM:09004 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6-Tg(Itgax-cre/ERT)61Gkl/Flmg
Alternative name	B6-Tg(Itgax-cre/ERT)61Gkl/Flmg
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Itgax-cre/ERT)61Gkl
Gene/Transgene symbol	Tg(Itgax-cre/ERT)61Gkl

Information from provider

Provider	George Kollias
Provider affiliation	BSRC Al. Fleming
Genetic information	The protein product of this transgene, whose transcription is under control of the dendritic cell- (DC-) specific mouse integrin alpha X (Itgax/Cdc11c) promoter, is a fusion of Cre recombinase and a mutant hormone-binding domain from human estrogen receptor 1 (ESR1).
Phenotypic information	Homozygous: No overt phenotype Heterozygous: No overt phenotype
References	Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.;Probst Hans Christian, Lagnel Jacques, Kollias George, van den Broek Maries, ;2003;Immunity;18;713-20; 12753747
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	B.S.R.C. Alexander Fleming, Vari, Greece

Literature references

Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.;Probst Hans Christian, Lagnel Jacques, Kollias George, van den Broek Maries, ;2003;Immunity;18;713-20; 12753747
An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination.;Barclay Kia M, Abduljawad Nora, Cheng Zuolin, Kim Min Woo, Zhou Lu, Yang Jin, Rustenhoven Justin, Mazzitelli Jose A, Smyth Leon C D, Kapadia Dvita, Brioschi Simone, Beatty Wandy, Hou JinChao, Saligrama Naresha, Colonna Marco, Yu Guoqiang, Kipnis Jonathan, Li Qingyun, ;2024;Immunity;57;1394-1412.e8; 38821054

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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