C57BL/6-Tg(Itgax-cre/ERT)61Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:09004 |
| International strain name | C57BL/6-Tg(Itgax-cre/ERT)61Gkl/Flmg |
| Alternative name | B6-Tg(Itgax-cre/ERT)61Gkl/Flmg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Itgax-cre/ERT)61Gkl |
| Gene/Transgene symbol | Tg(Itgax-cre/ERT)61Gkl |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Al. Fleming |
| Genetic information | The protein product of this transgene, whose transcription is under control of the dendritic cell- (DC-) specific mouse integrin alpha X (Itgax/Cdc11c) promoter, is a fusion of Cre recombinase and a mutant hormone-binding domain from human estrogen receptor 1 (ESR1). |
| Phenotypic information | Homozygous:No overt phenotypeHeterozygous:No overt phenotype |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Literature references
- Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.;Probst Hans Christian, Lagnel Jacques, Kollias George, van den Broek Maries, ;2003;Immunity;18;713-20; 12753747
- An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination.;Barclay Kia M, Abduljawad Nora, Cheng Zuolin, Kim Min Woo, Zhou Lu, Yang Jin, Rustenhoven Justin, Mazzitelli Jose A, Smyth Leon C D, Kapadia Dvita, Brioschi Simone, Beatty Wandy, Hou JinChao, Saligrama Naresha, Colonna Marco, Yu Guoqiang, Kipnis Jonathan, Li Qingyun, ;2024;Immunity;57;1394-1412.e8; 38821054