IMPC phenotypes (gene matching)
- decreased circulating serum albumin level / IMPC
C3HeB/FeJ-Gje1Mhdaaey12/Ieg
| Status | Available to order |
| EMMA ID | EM:00009 |
| International strain name | C3HeB/FeJ-Gje1Mhdaaey12/Ieg |
| Alternative name | AEY12 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Gje1Mhdaaey12 |
| Gene/Transgene symbol | Gje1 |
Information from provider
| Provider | Martin Hrabe de Angelis |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | See Puk O. et al, Invest Ophthalmol Vis Sci. (2008), PubMed ID: 18385072. Disclaimer - Special restrictions: 1) Mutant development was phenotype driven. Although for some mutant lines, linkage data and the molecular characterization of the causative mutation has been published, EMMA has not genotyped the strains and can not provide genotyping protocols. 2) Some lines showed low penetrance of the phenotype. 3) Only sperm available. Rederivation service can not be offered. 4) EMMA quality control standards may not apply for these strains. 5) EMMA has not verified the breeding performance and the genetic background of the strains. The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt. |
| Phenotypic information | Small eyes, stop of eye/lens development at the lens vesicle stage, no primary lens fibres formed. |
| Breeding history | Around five times backcrossed to C3HeB/FeJ. |
| References |
|
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal lens vesicle development / MGI
- microphthalmia / MGI
- abnormal lens morphology / MGI
- small lens / MGI
- abnormal cornea morphology / MGI
- corneal opacity / MGI
- abnormal retina morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal lens fiber morphology / MGI
- no phenotypic analysis / MGI
- abnormal lens development / MGI
- polar cataracts / MGI
Literature references
- Genome-wide, large-scale production of mutant mice by ENU mutagenesis.;Hrabé de Angelis M H, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R, ;2000;Nature genetics;25;444-7; 10932192
- Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype.;Puk Oliver, Löster Jana, Dalke Claudia, Soewarto Dian, Fuchs Helmut, Budde Birgit, Nürnberg Peter, Wolf Eckhard, de Angelis Martin Hrabé, Graw Jochen, ;2008;Investigative ophthalmology & visual science;49;1525-32; 18385072
- Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.;Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;528-30; 10886017