C57BL/6N-A^tm1Brd Ildr1^{tm1(KOMP)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:08997
International strain name	C57BL/6N-A^tm1Brd Ildr1^{tm1(KOMP)Wtsi}/WtsiH
Alternative name	EPD0384_1_C10
Strain type
Allele/Transgene symbol	Ildr1^{tm1(KOMP)Wtsi}
Gene/Transgene symbol	Ildr1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0384_1_C10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

autosomal recessive nonsyndromic deafness 42 / DOID:0110500

Orphanet associated rare diseases, based on orthologous gene matching

Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636

IMPC phenotypes (allele matching)

absent pinna reflex / IMPC

IMPC phenotypes (gene matching)

absent pinna reflex / IMPC

MGI phenotypes (allele matching)

abnormal organ of Corti morphology / MGI
deafness / MGI
abnormal endocochlear potential / MGI
cochlear inner hair cell degeneration / MGI
cochlear outer hair cell degeneration / MGI
abnormal inner hair cell stereociliary bundle morphology / MGI
sensorineural hearing loss / MGI
hearing/vestibular/ear phenotype / MGI
increased or absent threshold for auditory brainstem response / MGI

MGI phenotypes (gene matching)

abnormal inner ear morphology / MGI
abnormal organ of Corti morphology / MGI
organ of Corti degeneration / MGI
deafness / MGI
abnormal cochlear hair cell morphology / MGI
abnormal endocochlear potential / MGI
no phenotypic analysis / MGI
absent tunnel of Corti / MGI
cochlear inner hair cell degeneration / MGI
cochlear outer hair cell degeneration / MGI
abnormal outer hair cell stereociliary bundle morphology / MGI
abnormal inner hair cell stereociliary bundle morphology / MGI
absent distortion product otoacoustic emissions / MGI
sensorineural hearing loss / MGI
homeostasis/metabolism phenotype / MGI
hearing/vestibular/ear phenotype / MGI
growth/size/body region phenotype / MGI
digestive/alimentary phenotype / MGI
abnormal circulating hormone level / MGI
increased or absent threshold for auditory brainstem response / MGI
abnormal tunnel of Corti morphology / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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