C57BL/6NTac-Pyytm1(EGFP/cre/ERT2)Wtsi/Cnrm

Status

Available to order

EMMA IDEM:08970
International strain nameC57BL/6NTac-Pyytm1(EGFP/cre/ERT2)Wtsi/Cnrm
Alternative nameCEPD0036_1_A11
Strain type
Allele/Transgene symbolPyytm1(EGFP/cre/ERT2)Wtsi
Gene/Transgene symbolPyy

Information from provider

Provider CNR, Consiglio Nazionale delle Ricerche
Provider affiliationEMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0036_1_A11. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • increased white adipose tissue amount / MGI
  • abnormal adipose tissue distribution / MGI
  • increased bone mineral density / MGI
  • decreased bone mineral density / MGI
  • abnormal body weight / MGI
  • increased body weight / MGI
  • obese / MGI
  • polyphagia / MGI
  • increased circulating insulin level / MGI
  • no abnormal phenotype detected / MGI
  • increased circulating testosterone level / MGI
  • abnormal bone mineralization / MGI
  • abnormal lumbar vertebrae morphology / MGI
  • increased susceptibility to age related obesity / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal bone structure / MGI
  • increased lean body mass / MGI
  • decreased lean body mass / MGI
  • decreased bone mass / MGI
  • increased circulating insulin-like growth factor I level / MGI
  • impaired glucose tolerance / MGI
  • growth/size/body region phenotype / MGI
  • behavior/neurological phenotype / MGI
  • increased susceptibility to weight gain / MGI
  • increased percent body fat/body weight / MGI
  • abnormal hypothalamus physiology / MGI
  • increased circulating leptin level / MGI
  • increased gonadal fat pad weight / MGI
  • increased total body fat amount / MGI
  • decreased total body fat amount / MGI
  • increased bone mineral content / MGI
  • decreased bone mineral content / MGI
  • increased trabecular bone volume / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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