C57BL/6NTac-Ucp1tm1.1(EGFP/cre/ERT2)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:08947
International strain nameC57BL/6NTac-Ucp1tm1.1(EGFP/cre/ERT2)Wtsi/WtsiH
Alternative nameCEPD0007_1_C12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolUcp1tm1.1(EGFP/cre/ERT2)Wtsi
Gene/Transgene symbolUcp1

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0007_1_C12. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1.1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • thick ventricular wall / IMPC
  • increased erythrocyte cell number / IMPC
  • decreased circulating triglyceride level / IMPC
  • eye hemorrhage / IMPC
  • increased hemoglobin content / IMPC
  • abnormal sinus arrhythmia / IMPC
  • increased hematocrit / IMPC
  • corneal vascularization / IMPC
  • cataract / IMPC
  • abnormal lens morphology / IMPC
  • abnormal QT variability / IMPC
MGI phenotypes (gene matching)
  • increased brown adipose tissue amount / MGI
  • decreased body weight / MGI
  • abnormal body temperature homeostasis / MGI
  • decreased white adipose tissue amount / MGI
  • abnormal lipid homeostasis / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating free fatty acid level / MGI
  • abnormal oxygen consumption / MGI
  • decreased oxygen consumption / MGI
  • homeostasis/metabolism phenotype / MGI
  • decreased circulating thyroxine level / MGI
  • increased circulating triiodothyronine level / MGI
  • increased body temperature / MGI
  • decreased susceptibility to diet-induced obesity / MGI
  • abnormal mitochondrial physiology / MGI
  • abnormal physiological response to xenobiotic / MGI
  • decreased respiratory quotient / MGI
  • impaired adaptive thermogenesis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).