C57BL/6N-Atm1Brd Npattm1a(EUCOMM)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:08932
International strain nameC57BL/6N-Atm1Brd Npattm1a(EUCOMM)Wtsi/WtsiOulu
Alternative nameEPD0370_4_H05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolNpattm1a(EUCOMM)Wtsi
Gene/Transgene symbolNpat
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0370_4_H05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • rib fusion / MGI
  • abnormal interatrial septum morphology / MGI
  • double outlet right ventricle / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • abnormal adrenal gland morphology / MGI
  • small superior cervical ganglion / MGI
  • abnormal testis morphology / MGI
  • abnormal Mullerian duct morphology / MGI
  • fetal growth retardation / MGI
  • fusion of vertebral arches / MGI
  • abnormal humerus morphology / MGI
  • thoracoschisis / MGI
  • perimembraneous ventricular septal defect / MGI
  • double ureter / MGI
  • abnormal digastric muscle morphology / MGI
  • subcutaneous edema / MGI
  • abnormal ductus venosus valve morphology / MGI
  • abnormal ureter topology / MGI
  • abnormal infrahyoid muscle morphology / MGI
  • multiple persisting craniopharyngeal ducts / MGI
  • reduced sympathetic cervical ganglion size / MGI
  • blood in lymph vessels / MGI
  • symmetric azygos veins / MGI
  • abnormal vertebral artery origin / MGI
  • abnormal vertebral artery topology / MGI
  • abnormal intestine placement / MGI
  • retrolental blood / MGI
  • persistent trigeminal artery / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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