IMPC phenotypes (gene matching)
C57BL/6NTac-Lama5tm1a(KOMP)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:08811 |
| Citation information | RRID:IMSR_EM:08811 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Lama5tm1a(KOMP)Wtsi/H |
| Alternative name | EPD0179_1_C10 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Lama5tm1a(KOMP)Wtsi |
| Gene/Transgene symbol | Lama5 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from KOMP ES clone EPD0179_1_C10. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- LAMA5-related multisystemic syndrome / Orphanet_521450
MGI phenotypes (gene matching)
- lowered ear position / MGI
- absent neurocranium / MGI
- abnormal tooth development / MGI
- double outlet right ventricle / MGI
- abnormal head morphology / MGI
- megacephaly / MGI
- abnormal intestine morphology / MGI
- abnormal pulmonary artery morphology / MGI
- abnormal intestinal epithelium morphology / MGI
- absent kidney / MGI
- abnormal kidney development / MGI
- syndactyly / MGI
- abnormal autopod morphology / MGI
- mesocardia / MGI
- abnormal brain development / MGI
- exencephaly / MGI
- incomplete rostral neuropore closure / MGI
- abnormal lung morphology / MGI
- decreased body size / MGI
- anophthalmia / MGI
- microphthalmia / MGI
- abnormal embryo size / MGI
- abnormal placenta morphology / MGI
- thymus hypoplasia / MGI
- premature death / MGI
- abnormal extraembryonic tissue morphology / MGI
- abnormal limb morphology / MGI
- abnormal digit morphology / MGI
- persistent truncus arteriosis / MGI
- dilated renal tubules / MGI
- increased urine protein level / MGI
- small kidney / MGI
- no phenotypic analysis / MGI
- impaired basement membrane formation / MGI
- curly tail / MGI
- enlarged kidney / MGI
- left pulmonary isomerism / MGI
- renal interstitial fibrosis / MGI
- abnormal intestinal goblet cell morphology / MGI
- kidney failure / MGI
- abnormal nervous system morphology / MGI
- small lung / MGI
- kidney cysts / MGI
- absent ureter / MGI
- interrupted aortic arch / MGI
- right aortic arch / MGI
- decreased fetal size / MGI
- abnormal thoracic cavity morphology / MGI
- impaired branching involved in ureteric bud morphogenesis / MGI
- abnormal trophoblast layer morphology / MGI
- hematuria / MGI
- abnormal podocyte morphology / MGI
- abnormal mesangial cell morphology / MGI
- increased circulating creatinine level / MGI
- increased blood urea nitrogen level / MGI
- polycystic kidney / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- abnormal right lung morphology / MGI
- ventricular septal defect / MGI
- atrioventricular septal defect / MGI
- pulmonary artery hypoplasia / MGI
- vascular ring / MGI
- abnormal right subclavian artery morphology / MGI
- abnormal visceral pleura morphology / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- abnormal glomerular capillary morphology / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- increased kidney apoptosis / MGI
- abnormal glomerular capillary endothelium morphology / MGI
- decreased placental labyrinth size / MGI