C57BL/6N-Atm1Brd H13tm1a(KOMP)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:08694
Citation informationRRID:IMSR_EM:08694 

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International strain nameC57BL/6N-Atm1Brd H13tm1a(KOMP)Wtsi/WtsiH
Alternative nameEPD0867_5_D04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolH13tm1a(KOMP)Wtsi
Gene/Transgene symbolH13
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0867_5_D04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • decreased fasting circulating glucose level / IMPC
  • increased bone mineral content / IMPC
  • abnormal snout morphology / IMPC
MGI phenotypes (gene matching)
  • abnormal vertebrae morphology / MGI
  • abnormal rib morphology / MGI
  • absent ribs / MGI
  • abnormal interatrial septum morphology / MGI
  • double outlet right ventricle / MGI
  • absent kidney / MGI
  • enlarged liver sinusoidal spaces / MGI
  • abnormal forebrain morphology / MGI
  • abnormal olfactory bulb morphology / MGI
  • abnormal hindbrain morphology / MGI
  • exencephaly / MGI
  • fused dorsal root ganglion / MGI
  • absent superior cervical ganglion / MGI
  • small superior cervical ganglion / MGI
  • abnormal tail morphology / MGI
  • abnormal brain morphology / MGI
  • abnormal outer ear morphology / MGI
  • situs inversus / MGI
  • abnormal posterior semicircular canal morphology / MGI
  • small thyroid gland / MGI
  • small kidney / MGI
  • left pulmonary isomerism / MGI
  • abnormal forebrain development / MGI
  • abnormal nervous system morphology / MGI
  • abnormal eye muscle morphology / MGI
  • abnormal Mullerian duct morphology / MGI
  • abnormal Wolffian duct morphology / MGI
  • transposition of great arteries / MGI
  • retroesophageal right subclavian artery / MGI
  • abnormal optic stalk morphology / MGI
  • abnormal optic cup morphology / MGI
  • abnormal vertebral arch morphology / MGI
  • abnormal cervical atlas morphology / MGI
  • abnormal stapedial artery morphology / MGI
  • absent stapedial artery / MGI
  • decreased length of long bones / MGI
  • absent Mullerian ducts / MGI
  • abnormal styloid process morphology / MGI
  • abnormal brain internal capsule morphology / MGI
  • thoracoschisis / MGI
  • abnormal optic chiasm morphology / MGI
  • abnormal liver vasculature morphology / MGI
  • perimembraneous ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • abnormal hepatic vein morphology / MGI
  • abnormal inferior vena cava valve morphology / MGI
  • abnormal pulmonary valve cusp morphology / MGI
  • abnormal hypoglossal canal morphology / MGI
  • absent hypoglossal canal / MGI
  • thin hypoglossal nerve / MGI
  • absent hypoglossal nerve / MGI
  • abnormal hypoglossal nerve topology / MGI
  • absent segment of posterior cerebral artery / MGI
  • subcutaneous edema / MGI
  • absent celiac artery / MGI
  • abnormal azygos vein topology / MGI
  • abnormal vitelline vein connection / MGI
  • abnormal pancreas topology / MGI
  • enlarged paraumbilical vein / MGI
  • abnormal stapedial artery topology / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve morphology / MGI
  • abnormal brachial plexus formation / MGI
  • abnormal thymus topology / MGI
  • abnormal infrahyoid muscle morphology / MGI
  • abnormal infrahyoid muscle connection / MGI
  • multiple persisting craniopharyngeal ducts / MGI
  • reduced sympathetic cervical ganglion size / MGI
  • blood in lymph vessels / MGI
  • symmetric azygos veins / MGI
  • abnormal umbilical vein topology / MGI
  • abnormal vitelline vein topology / MGI
  • persistent dorsal ophthalmic artery / MGI
  • abnormal vertebral artery origin / MGI
  • absent posterior communicating artery / MGI
  • embryo tumor / MGI
  • heterochrony / MGI
  • abnormal intestine placement / MGI
  • absent inferior vena cava / MGI

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