C57BL/6N-Tardbp^{tm1a(EUCOMM)Wtsi}/H

Status	Available to order
EMMA ID	EM:08625
International strain name	C57BL/6N-Tardbp^{tm1a(EUCOMM)Wtsi}/H
Alternative name	EPD0828_4_C03
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Tardbp^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Tardbp
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from EUCOMM ES clone EPD0828_4_C03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)

MGI phenotypes (gene matching)

increased body weight / MGI
abnormal locomotor behavior / MGI
impaired coordination / MGI
abnormal eating behavior / MGI
polyphagia / MGI
abnormal object recognition memory / MGI
limb grasping / MGI
abnormal learning/memory/conditioning / MGI
abnormal motor capabilities/coordination/movement / MGI
increased vertical activity / MGI
no phenotypic analysis / MGI
impaired muscle relaxation / MGI
abnormal GABAergic neuron morphology / MGI
nervous system phenotype / MGI
decreased stereotypic behavior / MGI
abnormal brain interneuron morphology / MGI
abnormal muscle tone / MGI
behavior/neurological phenotype / MGI
slow postnatal weight gain / MGI
decreased grip strength / MGI
prenatal lethality, complete penetrance / MGI
embryonic lethality, complete penetrance / MGI
embryonic lethality between implantation and somite formation, complete penetrance / MGI
preweaning lethality, incomplete penetrance / MGI
absent inner cell mass proliferation / MGI
embryonic lethality prior to organogenesis / MGI
abnormal cognition / MGI
cognitive inflexibility / MGI

Information from provider