- decreased lean body mass / IMPC
- decreased red blood cell distribution width / IMPC
- increased circulating alkaline phosphatase level / IMPC
- preweaning lethality, complete penetrance / IMPC
- abnormal retina morphology / IMPC
- decreased neutrophil cell number / IMPC
- absent spleen / IMPC
- decreased grip strength / IMPC
- embryonic lethality prior to tooth bud stage / IMPC
- embryonic lethality prior to organogenesis / IMPC
B6.Cg-Dicer1tm1.1Doca/Cnrm
Status | Available to order |
EMMA ID | EM:08527 |
Citation information | RRID:IMSR_EM:08527 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | B6.Cg-Dicer1tm1.1Doca/Cnrm |
Alternative name | FH-Dicer |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Dicer1tm1.1Doca |
Gene/Transgene symbol | Dicer1 |
Information from provider
Provider | Donal O'Carroll |
Provider affiliation | EMBL Monterotondo |
Genetic information | Knock-in strain expressing a N-terminally FLAG-HA2 epitope-tagged Dicer. |
Phenotypic information | Homozygous:No phenotype observed.Heterozygous:No phenotype observed. |
Breeding history | The mice were generated by targeting ES cells of A9/129/Sv background and by backcrossing heterozygotes to B6N mice (8 generations at the moment). |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Global developmental delay-lung cysts-overgrowth-Wilms tumor syndrome / Orphanet_404476
- Pleuropulmonary blastoma familial tumor susceptibility syndrome / Orphanet_284343
- Embryonal rhabdomyosarcoma / Orphanet_99757
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal angiogenesis / MGI
- small liver / MGI
- abnormal blood vessel morphology / MGI
- abnormal embryo development / MGI
- decreased embryo size / MGI
- absent vitelline blood vessels / MGI
- embryonic growth arrest / MGI
- female infertility / MGI
- no abnormal phenotype detected / MGI
- decreased susceptibility to viral infection / MGI
- increased susceptibility to viral infection / MGI
- no phenotypic analysis / MGI
- abnormal vitelline vascular remodeling / MGI
- increased B-1 B cell number / MGI
- decreased T cell number / MGI
- abnormal female meiosis / MGI
- reproductive system phenotype / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased single-positive T cell number / MGI
- abnormal meiotic spindle morphology / MGI
- increased effector memory CD4-positive, alpha-beta T cell number / MGI
- increased central memory CD8 positive, alpha-beta T cell number / MGI
- increased effector memory CD8-positive, alpha-beta T cell number / MGI
- perinatal lethality, incomplete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased CD8-positive, naive alpha-beta T cell number / MGI
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