B6.Cg-Dicer1tm1.1Doca/Cnrm

Status

Available to order

EMMA IDEM:08527
International strain nameB6.Cg-Dicer1tm1.1Doca/Cnrm
Alternative nameFH-Dicer
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolDicer1tm1.1Doca
Gene/Transgene symbolDicer1

Information from provider

ProviderDonal O'Carroll
Provider affiliationEMBL Monterotondo
Genetic informationKnock-in strain expressing a N-terminally FLAG-HA2 epitope-tagged Dicer.
Phenotypic informationHomozygous:
No phenotype observed.

Heterozygous:
No phenotype observed.
Breeding historyThe mice were generated by targeting ES cells of A9/129/Sv background and by backcrossing heterozygotes to B6N mice (8 generations at the moment).
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased lean body mass / IMPC
  • decreased red blood cell distribution width / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal retina morphology / IMPC
  • decreased neutrophil cell number / IMPC
  • absent spleen / IMPC
  • decreased grip strength / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • embryonic lethality prior to organogenesis / IMPC
MGI phenotypes (gene matching)
  • abnormal angiogenesis / MGI
  • small liver / MGI
  • abnormal blood vessel morphology / MGI
  • abnormal embryo development / MGI
  • decreased embryo size / MGI
  • absent vitelline blood vessels / MGI
  • embryonic growth arrest / MGI
  • female infertility / MGI
  • no abnormal phenotype detected / MGI
  • decreased susceptibility to viral infection / MGI
  • increased susceptibility to viral infection / MGI
  • no phenotypic analysis / MGI
  • abnormal vitelline vascular remodeling / MGI
  • increased B-1 B cell number / MGI
  • decreased T cell number / MGI
  • abnormal female meiosis / MGI
  • reproductive system phenotype / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • abnormal meiotic spindle morphology / MGI
  • increased effector memory CD4-positive, alpha-beta T cell number / MGI
  • increased central memory CD8 positive, alpha-beta T cell number / MGI
  • increased effector memory CD8-positive, alpha-beta T cell number / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • decreased CD8-positive, naive alpha-beta T cell number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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