- decreased lean body mass / IMPC
- decreased red blood cell distribution width / IMPC
- increased circulating alkaline phosphatase level / IMPC
- preweaning lethality, complete penetrance / IMPC
- abnormal retina morphology / IMPC
- decreased neutrophil cell number / IMPC
- absent spleen / IMPC
- decreased grip strength / IMPC
- embryonic lethality prior to tooth bud stage / IMPC
- embryonic lethality prior to organogenesis / IMPC
B6.Cg-Dicer1tm1.1Doca/Cnrm
Status | Available to order |
EMMA ID | EM:08527 |
International strain name | B6.Cg-Dicer1tm1.1Doca/Cnrm |
Alternative name | FH-Dicer |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Dicer1tm1.1Doca |
Gene/Transgene symbol | Dicer1 |
Information from provider
Provider | Donal O'Carroll |
Provider affiliation | EMBL Monterotondo |
Genetic information | Knock-in strain expressing a N-terminally FLAG-HA2 epitope-tagged Dicer. |
Phenotypic information | Homozygous:No phenotype observed.Heterozygous:No phenotype observed. |
Breeding history | The mice were generated by targeting ES cells of A9/129/Sv background and by backcrossing heterozygotes to B6N mice (8 generations at the moment). |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Global developmental delay-lung cysts-overgrowth-Wilms tumor syndrome / Orphanet_404476
- Pleuropulmonary blastoma familial tumor susceptibility syndrome / Orphanet_284343
- Embryonal rhabdomyosarcoma / Orphanet_99757
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal angiogenesis / MGI
- small liver / MGI
- abnormal blood vessel morphology / MGI
- abnormal embryo development / MGI
- decreased embryo size / MGI
- absent vitelline blood vessels / MGI
- embryonic growth arrest / MGI
- female infertility / MGI
- no abnormal phenotype detected / MGI
- decreased susceptibility to viral infection / MGI
- increased susceptibility to viral infection / MGI
- no phenotypic analysis / MGI
- abnormal vitelline vascular remodeling / MGI
- increased B-1 B cell number / MGI
- decreased T cell number / MGI
- abnormal female meiosis / MGI
- reproductive system phenotype / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased single-positive T cell number / MGI
- abnormal meiotic spindle morphology / MGI
- increased effector memory CD4-positive, alpha-beta T cell number / MGI
- increased central memory CD8 positive, alpha-beta T cell number / MGI
- increased effector memory CD8-positive, alpha-beta T cell number / MGI
- perinatal lethality, incomplete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased CD8-positive, naive alpha-beta T cell number / MGI
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