C57BL/6N-Prkg1tm1a(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:08524
International strain nameC57BL/6N-Prkg1tm1a(KOMP)Wtsi/H
Alternative nameEPD0553_5_B04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolPrkg1tm1a(KOMP)Wtsi
Gene/Transgene symbolPrkg1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0553_5_B04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • enlarged spleen / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • enlarged heart / IMPC
  • increased startle reflex / IMPC
  • abnormal duodenum morphology / IMPC
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal systemic arterial blood pressure / MGI
  • hypertension / MGI
  • abnormal blood vessel physiology / MGI
  • abnormal intestine morphology / MGI
  • enlarged spleen / MGI
  • impaired smooth muscle contractility / MGI
  • abnormal penile erection / MGI
  • anemia / MGI
  • decreased brown adipose tissue amount / MGI
  • reduced male fertility / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • abnormal erythrocyte morphology / MGI
  • increased mean corpuscular volume / MGI
  • reticulocytosis / MGI
  • increased systemic arterial blood pressure / MGI
  • decreased erythrocyte cell number / MGI
  • abnormal cardiac muscle contractility / MGI
  • impaired muscle relaxation / MGI
  • abnormal intestinal peristalsis / MGI
  • pyloric stenosis / MGI
  • decreased cardiac output / MGI
  • abnormal cardiac muscle relaxation / MGI
  • salt-resistant hypertension / MGI
  • increased mean systemic arterial blood pressure / MGI
  • decreased triglyceride level / MGI
  • renal/urinary system phenotype / MGI
  • abnormal circulating hormone level / MGI
  • increased mean corpuscular hemoglobin / MGI
  • decreased vasodilation / MGI
  • abnormal vascular smooth muscle physiology / MGI
  • abnormal intestinal transit time / MGI
  • increased systemic arterial diastolic blood pressure / MGI
  • increased systemic arterial systolic blood pressure / MGI
  • decreased brown fat cell lipid droplet size / MGI
  • increased erythrocyte clearance / MGI
  • increased red blood cell distribution width / MGI
  • pyloric sphincter hypertrophy / MGI
  • stomach fundus hypertrophy / MGI
  • decreased body surface temperature / MGI
  • postnatal lethality, complete penetrance / MGI
  • abnormal adipose tissue development / MGI
  • decreased mitochondrial DNA content / MGI
  • abnormal brown adipose tissue thermogenesis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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