C57BL/6N-A^tm1Brd Xpnpep1^{tm1a(KOMP)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:08521
International strain name	C57BL/6N-A^tm1Brd Xpnpep1^{tm1a(KOMP)Wtsi}/WtsiH
Alternative name	EPD0383_7_C09
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Xpnpep1^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Xpnpep1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0383_7_C09. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)

abnormal cranium morphology / IMPC
increased NK cell number / IMPC
increased gamma-delta T cell number / IMPC
preweaning lethality, incomplete penetrance / IMPC

IMPC phenotypes (gene matching)

increased NK cell number / IMPC
increased gamma-delta T cell number / IMPC
abnormal cranium morphology / IMPC
preweaning lethality, incomplete penetrance / IMPC

MGI phenotypes (allele matching)

abnormal mitral valve morphology / MGI
enlarged liver sinusoidal spaces / MGI
abnormal thymus morphology / MGI
abnormal aortic valve morphology / MGI
abnormal bile duct morphology / MGI
abnormal eye muscle morphology / MGI
abnormal Mullerian duct morphology / MGI
abnormal inferior vena cava morphology / MGI
abnormal superior vena cava morphology / MGI
muscular ventricular septal defect / MGI
abnormal inferior vena cava valve morphology / MGI
abnormal hypoglossal nerve topology / MGI
subcutaneous edema / MGI
trigeminal neuroma / MGI
abnormal infrahyoid muscle morphology / MGI
abnormal infrahyoid muscle connection / MGI
blood in lymph vessels / MGI
abnormal umbilical vein topology / MGI
abnormal vitelline vein topology / MGI
abnormal vertebral artery topology / MGI
embryo tumor / MGI
abnormal intestine placement / MGI

MGI phenotypes (gene matching)

abnormal mitral valve morphology / MGI
microcephaly / MGI
enlarged liver sinusoidal spaces / MGI
abnormal thymus morphology / MGI
decreased brain size / MGI
forebrain hypoplasia / MGI
decreased body length / MGI
decreased body weight / MGI
decreased body size / MGI
postnatal growth retardation / MGI
abnormal aortic valve morphology / MGI
abnormal bile duct morphology / MGI
increased urine protein level / MGI
abnormal urine color / MGI
abnormal eye muscle morphology / MGI
abnormal Mullerian duct morphology / MGI
abnormal inferior vena cava morphology / MGI
abnormal superior vena cava morphology / MGI
decreased birth body size / MGI
muscular ventricular septal defect / MGI
abnormal inferior vena cava valve morphology / MGI
abnormal survival / MGI
postnatal lethality, complete penetrance / MGI
postnatal lethality, incomplete penetrance / MGI
prenatal lethality, incomplete penetrance / MGI
abnormal hypoglossal nerve topology / MGI
subcutaneous edema / MGI
trigeminal neuroma / MGI
abnormal infrahyoid muscle morphology / MGI
abnormal infrahyoid muscle connection / MGI
blood in lymph vessels / MGI
abnormal umbilical vein topology / MGI
abnormal vitelline vein topology / MGI
abnormal vertebral artery topology / MGI
embryo tumor / MGI
abnormal intestine placement / MGI
hemangioma / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Reporterless null allele (tm1d allele), service fee and delivery time available upon request
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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