C3;C-Emx2Pdo/H

Status

Available to order

EMMA IDEM:00085
International strain nameC3;C-Emx2Pdo/H
Alternative nameGENA181
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolEmx2Pdo
Gene/Transgene symbolEmx2

Information from provider

ProviderNick Parkinson
Provider affiliationMRC Mammalian Genetics Unit
Phenotypic informationThese mice have a malformed ossicular chain in the middle ear which leads to conductive hearing loss. In addition, a developmental aberration in inner ear stereocilia patterning leads to an extra row of inner and outer hair cells and sensoneural deafness.
References
  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal malleus morphology / MGI
  • deafness / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • decreased cochlear nerve compound action potential / MGI
  • conductive hearing loss / MGI
  • sensorineural hearing loss / MGI
  • syndromic hearing loss / MGI
  • abnormal middle ear ossicle morphology / MGI
  • cardiovascular system phenotype / MGI
  • absent pinna reflex / MGI
  • abnormal incudostapedial joint morphology / MGI
  • abnormal incudomalleolar joint morphology / MGI
  • abnormal incus long process morphology / MGI
  • absent incus lenticular process / MGI
  • abnormal stapes head morphology / MGI
  • abnormal cochlea morphology / MGI
  • abnormal cochlear inner hair cell morphology / MGI
  • increased cochlear nerve compound action potential / MGI
  • abnormal incus morphology / MGI
  • abnormal stapes morphology / MGI
  • impaired hearing / MGI
  • small kidney / MGI
  • absent incus / MGI
  • neonatal lethality, complete penetrance / MGI
MGI phenotypes (gene matching)
  • abnormal malleus morphology / MGI
  • abnormal cochlea morphology / MGI
  • absent kidney / MGI
  • abnormal kidney development / MGI
  • decreased corpus callosum size / MGI
  • abnormal cerebral cortex morphology / MGI
  • absent dentate gyrus / MGI
  • abnormal Ammon gyrus morphology / MGI
  • abnormal lateral ventricle morphology / MGI
  • dilated third ventricle / MGI
  • deafness / MGI
  • abnormal primary sex determination / MGI
  • small olfactory bulb / MGI
  • small kidney / MGI
  • abnormal hippocampal fimbria morphology / MGI
  • absent vas deferens / MGI
  • absent uterus / MGI
  • absent oviduct / MGI
  • absent ovary / MGI
  • absent seminal vesicle / MGI
  • absent ureter / MGI
  • abnormal pallium development / MGI
  • absent incus / MGI
  • abnormal cochlear inner hair cell morphology / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • decreased cochlear nerve compound action potential / MGI
  • absent epididymis / MGI
  • absent efferent ductules of testis / MGI
  • conductive hearing loss / MGI
  • sensorineural hearing loss / MGI
  • syndromic hearing loss / MGI
  • increased cochlear nerve compound action potential / MGI
  • impaired branching involved in ureteric bud morphogenesis / MGI
  • abnormal middle ear ossicle morphology / MGI
  • abnormal incus morphology / MGI
  • abnormal stapes morphology / MGI
  • cardiovascular system phenotype / MGI
  • agonadal / MGI
  • impaired hearing / MGI
  • absent pinna reflex / MGI
  • absent testes / MGI
  • absent Mullerian ducts / MGI
  • decreased anterior commissure size / MGI
  • abnormal cerebral hemisphere morphology / MGI
  • absent cranial vagina / MGI
  • Wolffian duct degeneration / MGI
  • absent internal male genitalia / MGI
  • absent internal female genitalia / MGI
  • abnormal metanephric mesenchyme morphology / MGI
  • neonatal lethality, complete penetrance / MGI
  • increased metanephric mesenchyme apoptosis / MGI
  • gonadal ridge hypoplasia / MGI
  • abnormal metanephric ureteric bud development / MGI
  • abnormal ureteric bud tip morphology / MGI
  • decreased hippocampal fornix size / MGI
  • abnormal incudostapedial joint morphology / MGI
  • abnormal incudomalleolar joint morphology / MGI
  • abnormal incus long process morphology / MGI
  • absent incus lenticular process / MGI
  • abnormal stapes head morphology / MGI

Literature references

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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