C3;C-Emx2^Pdo/H

Status	Available to order
EMMA ID	EM:00085
Citation information	RRID:IMSR_EM:00085 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C3;C-Emx2^Pdo/H
Alternative name	GENA181
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Emx2^Pdo
Gene/Transgene symbol	Emx2

Information from provider

Provider	Nick Parkinson
Provider affiliation	MRC Mammalian Genetics Unit
Phenotypic information	These mice have a malformed ossicular chain in the middle ear which leads to conductive hearing loss. In addition, a developmental aberration in inner ear stereocilia patterning leads to an extra row of inner and outer hair cells and sensoneural deafness.
References	A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)

abnormal malleus morphology / MGI
deafness / MGI
increased cochlear inner hair cell number / MGI
increased cochlear outer hair cell number / MGI
decreased cochlear nerve compound action potential / MGI
conductive hearing loss / MGI
sensorineural hearing loss / MGI
syndromic hearing loss / MGI
abnormal middle ear ossicle morphology / MGI
cardiovascular system phenotype / MGI
absent pinna reflex / MGI
abnormal incudostapedial joint morphology / MGI
abnormal incudomalleolar joint morphology / MGI
abnormal incus long process morphology / MGI
absent incus lenticular process / MGI
abnormal stapes head morphology / MGI
abnormal cochlea morphology / MGI
abnormal cochlear inner hair cell morphology / MGI
increased cochlear nerve compound action potential / MGI
abnormal incus morphology / MGI
abnormal stapes morphology / MGI
impaired hearing / MGI
small kidney / MGI
absent incus / MGI
neonatal lethality, complete penetrance / MGI

MGI phenotypes (gene matching)

abnormal malleus morphology / MGI
abnormal cochlea morphology / MGI
absent kidney / MGI
abnormal kidney development / MGI
decreased corpus callosum size / MGI
abnormal cerebral cortex morphology / MGI
absent dentate gyrus / MGI
abnormal Ammon gyrus morphology / MGI
abnormal lateral ventricle morphology / MGI
dilated third ventricle / MGI
deafness / MGI
abnormal primary sex determination / MGI
small olfactory bulb / MGI
small kidney / MGI
abnormal hippocampal fimbria morphology / MGI
absent vas deferens / MGI
absent uterus / MGI
absent oviduct / MGI
absent ovary / MGI
absent seminal vesicle / MGI
absent ureter / MGI
abnormal pallium development / MGI
absent incus / MGI
abnormal cochlear inner hair cell morphology / MGI
increased cochlear inner hair cell number / MGI
increased cochlear outer hair cell number / MGI
decreased cochlear nerve compound action potential / MGI
absent epididymis / MGI
absent efferent ductules of testis / MGI
conductive hearing loss / MGI
sensorineural hearing loss / MGI
syndromic hearing loss / MGI
increased cochlear nerve compound action potential / MGI
impaired branching involved in ureteric bud morphogenesis / MGI
abnormal middle ear ossicle morphology / MGI
abnormal incus morphology / MGI
abnormal stapes morphology / MGI
cardiovascular system phenotype / MGI
agonadal / MGI
impaired hearing / MGI
absent pinna reflex / MGI
absent testes / MGI
absent Mullerian ducts / MGI
decreased anterior commissure size / MGI
abnormal cerebral hemisphere morphology / MGI
absent cranial vagina / MGI
Wolffian duct degeneration / MGI
absent internal male genitalia / MGI
absent internal female genitalia / MGI
abnormal metanephric mesenchyme morphology / MGI
neonatal lethality, complete penetrance / MGI
increased metanephric mesenchyme apoptosis / MGI
gonadal ridge hypoplasia / MGI
abnormal metanephric ureteric bud development / MGI
abnormal ureteric bud tip morphology / MGI
decreased hippocampal fornix size / MGI
abnormal incudostapedial joint morphology / MGI
abnormal incudomalleolar joint morphology / MGI
abnormal incus long process morphology / MGI
absent incus lenticular process / MGI
abnormal stapes head morphology / MGI

Literature references

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.

C3;C-Emx2Pdo/H