C57BL/6N-Adipor2^{tm1a(EUCOMM)Hmgu}/H

Status	Available to order
EMMA ID	EM:08492
International strain name	C57BL/6N-Adipor2^{tm1a(EUCOMM)Hmgu}/H
Alternative name	HEPD0751_3_F06
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Adipor2^{tm1a(EUCOMM)Hmgu}
Gene/Transgene symbol	Adipor2
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from EUCOMM ES clone HEPD0751_3_F06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)

small testis / IMPC
decreased lymphocyte cell number / IMPC
increased neutrophil cell number / IMPC
male infertility / IMPC
limb grasping / IMPC
decreased grip strength / IMPC

MGI phenotypes (gene matching)

abnormal abdominal fat pad morphology / MGI
decreased circulating LDL cholesterol level / MGI
decreased circulating HDL cholesterol level / MGI
seminiferous tubule degeneration / MGI
abnormal spermatogenesis / MGI
hyperactivity / MGI
hyperglycemia / MGI
abnormal glucose homeostasis / MGI
increased circulating insulin level / MGI
abnormal lipid homeostasis / MGI
increased brain weight / MGI
decreased circulating triglyceride level / MGI
oligozoospermia / MGI
decreased circulating insulin level / MGI
decreased pancreatic beta cell number / MGI
abnormal hormone level / MGI
decreased lean body mass / MGI
decreased testis weight / MGI
increased energy expenditure / MGI
increased adiponectin level / MGI
decreased epididymis weight / MGI
decreased circulating VLDL cholesterol level / MGI
decreased circulating cholesterol level / MGI
improved glucose tolerance / MGI
impaired glucose tolerance / MGI
insulin resistance / MGI
homeostasis/metabolism phenotype / MGI
decreased percent body fat/body weight / MGI
increased circulating glucose level / MGI
decreased susceptibility to diet-induced obesity / MGI
abnormal brown fat cell morphology / MGI
decreased fat cell size / MGI
decreased gonadal fat pad weight / MGI
decreased renal fat pad weight / MGI
decreased liver triglyceride level / MGI
abnormal adaptive thermogenesis / MGI
impaired adaptive thermogenesis / MGI
increased food intake / MGI
decreased brown adipose tissue mass / MGI
multinucleated giant male germ cells / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Reporterless null allele (tm1d allele), service fee and delivery time available upon request
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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