C57BL/6N-Adipor1tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:08491
International strain nameC57BL/6N-Adipor1tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0757_5_B12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAdipor1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolAdipor1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0757_5_B12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased total retina thickness / IMPC
  • increased circulating alanine transaminase level / IMPC
  • abnormal retina morphology / IMPC
  • decreased lymphocyte cell number / IMPC
  • increased circulating cholesterol level / IMPC
  • abnormal retina outer nuclear layer morphology / IMPC
  • decreased circulating calcium level / IMPC
  • increased circulating phosphate level / IMPC
  • increased neutrophil cell number / IMPC
  • decreased hemoglobin content / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • decreased cornea thickness / IMPC
  • increased red blood cell distribution width / IMPC
  • increased blood urea nitrogen level / IMPC
  • abnormal heart left ventricle morphology / IMPC
  • decreased exploration in new environment / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • abnormal auditory brainstem response / IMPC
  • increased circulating triglyceride level / IMPC
MGI phenotypes (gene matching)
  • increased brown adipose tissue amount / MGI
  • increased white adipose tissue amount / MGI
  • hypoactivity / MGI
  • hyperglycemia / MGI
  • abnormal glucose homeostasis / MGI
  • increased circulating insulin level / MGI
  • abnormal lipid homeostasis / MGI
  • no abnormal phenotype detected / MGI
  • decreased energy expenditure / MGI
  • decreased adiponectin level / MGI
  • increased circulating cholesterol level / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • increased susceptibility to weight gain / MGI
  • increased percent body fat/body weight / MGI
  • increased circulating glucose level / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • increased circulating leptin level / MGI
  • increased liver triglyceride level / MGI
  • abnormal adaptive thermogenesis / MGI
  • impaired adaptive thermogenesis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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