| Status | Available to order |
| EMMA ID | EM:08489 |
| Citation information | RRID:IMSR_EM:08489 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Tdrd9tm1Embrp/Cnrm |
| Alternative name | Tdrd9 KI (E257Q) cKO+Neo. |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Tdrd9tm1Embrp |
| Gene/Transgene symbol | Tdrd9 |
| Provider | Ramesh PILLAI |
| Provider affiliation | Grenoble Outstation, EMBL |
| Genetic information | The Tdrd9 gene carries a single point mutation (E257Q) in the ATPase motif (exon 5) that is predicted to kill its activity. Presence of loxP sites flanking exons 3-5 allows generation of conditional KOs. Note that the Neo cassette used for selection of the targeted ES cell line (A9 ES cells) is retained in the mouse line. |
| Phenotypic information | Homozygous:Homozygous KI males are infertile.Heterozygous:Males and females are viable and fertile. |
| Breeding history | The founder male was generated with targeted A9 ES cells injected into C57BL/6N host embryos. The founder was crossed with C57BL/6N females. The F1 generation was genotyped for presence of the targeted allele. |
| References |
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| Homozygous fertile | females only |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Orphanet associated rare diseases, based on orthologous gene matching
