C57BL/6N-Atm1Brd Tent5ctm1a(KOMP)Wtsi/WtsiFlmg

Status

Available to order

EMMA IDEM:08485
International strain nameC57BL/6N-Atm1Brd Tent5ctm1a(KOMP)Wtsi/WtsiFlmg
Alternative nameEPD0824_2_A02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTent5ctm1a(KOMP)Wtsi
Gene/Transgene symbolTent5c
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0824_2_A02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased grip strength / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
MGI phenotypes (gene matching)
  • cleft palate / MGI
  • abnormal small intestine placement / MGI
  • abnormal forebrain morphology / MGI
  • hemorrhage / MGI
  • decreased mean corpuscular volume / MGI
  • decreased hemoglobin content / MGI
  • abnormal bile duct morphology / MGI
  • small kidney / MGI
  • increased erythrocyte cell number / MGI
  • abnormal Mullerian duct morphology / MGI
  • fusion of vertebral arches / MGI
  • decreased B cell proliferation / MGI
  • decreased mean corpuscular hemoglobin concentration / MGI
  • hypochromic microcytic anemia / MGI
  • muscular ventricular septal defect / MGI
  • abnormal hepatic vein morphology / MGI
  • dual inferior vena cava / MGI
  • subcutaneous edema / MGI
  • absent ductus venosus valve / MGI
  • absent connection between subcutaneous lymph vessels and lymph sac / MGI
  • blood in lymph vessels / MGI
  • abnormal vertebral artery topology / MGI
  • additional anastomosis between intracranial vertebral arteries / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).