C57BL/6N-Atm1Brd Tmem127tm1(KOMP)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:08447
International strain nameC57BL/6N-Atm1Brd Tmem127tm1(KOMP)Wtsi/WtsiOulu
Alternative nameEPD0406_4_C10
Strain type
Allele/Transgene symbolTmem127tm1(KOMP)Wtsi
Gene/Transgene symbolTmem127
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0406_4_C10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased neutrophil cell number / IMPC
  • decreased monocyte cell number / IMPC
  • abnormal nail morphology / IMPC
  • tremors / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • thrombocytopenia / IMPC
  • increased T cell number / IMPC
  • decreased B cell number / IMPC
  • increased circulating bilirubin level / IMPC
  • increased circulating creatinine level / IMPC
  • decreased NK cell number / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • decreased CD4-positive, alpha-beta T cell number / IMPC
  • increased CD8-positive, alpha-beta T cell number / IMPC
  • decreased plasmacytoid dendritic cell number / IMPC
  • decreased B-2 B cell number / IMPC
  • increased circulating amylase level / IMPC
  • increased bone mineral content / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • increased alpha-beta T cell number / IMPC
  • increased KLRG1-positive NK cell number / IMPC
  • decreased KLRG1-positive NK cell number / IMPC
  • obsolete increased CD8-positive, alpha beta T cell number / IMPC
  • decreased Ly6C high monocyte number / IMPC
  • increased Ly6C low monocyte number / IMPC
  • decreased memory-marker NK cell number / IMPC
  • increased memory-marker NK cell number / IMPC
  • increased CD8-positive, naive alpha-beta T cell number / IMPC
  • decreased KLRG1-positive T-helper cell number / IMPC
IMPC phenotypes (gene matching)
  • increased CD8-positive, alpha-beta T cell number / IMPC
  • increased alpha-beta T cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased neutrophil cell number / IMPC
  • decreased CD4-positive, alpha-beta T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased plasmacytoid dendritic cell number / IMPC
  • increased T cell number / IMPC
  • decreased KLRG1-positive T-helper cell number / IMPC
  • tremors / IMPC
  • increased circulating amylase level / IMPC
  • decreased B cell number / IMPC
  • increased memory-marker NK cell number / IMPC
  • obsolete increased CD8-positive, alpha beta T cell number / IMPC
  • increased bone mineral content / IMPC
  • decreased monocyte cell number / IMPC
  • thrombocytopenia / IMPC
  • increased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased KLRG1-positive NK cell number / IMPC
  • decreased NK cell number / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • decreased B-2 B cell number / IMPC
  • abnormal nail morphology / IMPC
  • increased Ly6C low monocyte number / IMPC
  • decreased KLRG1-positive NK cell number / IMPC
  • decreased Ly6C high monocyte number / IMPC
  • increased circulating creatinine level / IMPC
  • decreased memory-marker NK cell number / IMPC
  • increased circulating bilirubin level / IMPC
MGI phenotypes (gene matching)
  • abnormal cell morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal lysosome physiology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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