C57BL/6N-A^tm1Brd Traf6^{tm2a(EUCOMM)Wtsi}/WtsiOulu

Status	Available to order
EMMA ID	EM:08446
International strain name	C57BL/6N-A^tm1Brd Traf6^{tm2a(EUCOMM)Wtsi}/WtsiOulu
Alternative name	EPD0530_9_H08
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Traf6^{tm2a(EUCOMM)Wtsi}
Gene/Transgene symbol	Traf6
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from EUCOMM ES clone EPD0530_9_H08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	University of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Autosomal dominant hypohidrotic ectodermal dysplasia / Orphanet_1810

IMPC phenotypes (allele matching)

increased grip strength / IMPC
preweaning lethality, complete penetrance / IMPC

IMPC phenotypes (gene matching)

increased grip strength / IMPC
preweaning lethality, complete penetrance / IMPC

MGI phenotypes (allele matching)

abnormal forebrain morphology / MGI
abnormal olfactory bulb morphology / MGI
exencephaly / MGI
abnormal kidney morphology / MGI
abnormal brain morphology / MGI
abnormal brain commissure morphology / MGI
dilated bile duct / MGI
intestinal/bowel diverticulum / MGI
bifid ureter / MGI
abnormal eye muscle morphology / MGI
abnormal Mullerian duct morphology / MGI
abnormal Wolffian duct morphology / MGI
abnormal myocardium compact layer morphology / MGI
abnormal optic stalk morphology / MGI
abnormal optic cup morphology / MGI
absent stapedial artery / MGI
abnormal stapes morphology / MGI
perimembraneous ventricular septal defect / MGI
muscular ventricular septal defect / MGI
persistent right dorsal aorta / MGI
herniated liver / MGI
umbilical vein stenosis / MGI
thin hypoglossal nerve / MGI
ductus venosus stenosis / MGI
subcutaneous edema / MGI
absent ductus venosus valve / MGI
abnormal ductus venosus valve topology / MGI
persistent right 6th pharyngeal arch artery / MGI
abnormal endolymphatic sac topology / MGI
multiple persisting craniopharyngeal ducts / MGI
blood in lymph vessels / MGI
abnormal coronary sinus connection / MGI
abnormal vitelline vein topology / MGI
abnormal vertebral artery topology / MGI

MGI phenotypes (gene matching)

increased bone mineral density / MGI
osteopetrosis / MGI
failure of tooth eruption / MGI
absent incisors / MGI
abnormal long bone metaphysis morphology / MGI
decreased circulating phosphate level / MGI
enlarged heart / MGI
abnormal coat/ hair morphology / MGI
alopecia / MGI
absent eccrine glands / MGI
kinked tail / MGI
enlarged liver / MGI
abnormal sebaceous gland morphology / MGI
abnormal spleen morphology / MGI
enlarged spleen / MGI
abnormal forebrain morphology / MGI
abnormal olfactory bulb morphology / MGI
exencephaly / MGI
translucent skin / MGI
decreased body length / MGI
decreased body weight / MGI
decreased body size / MGI
abnormal osteoclast physiology / MGI
postnatal growth retardation / MGI
abnormal skin pigmentation / MGI
abnormal kidney morphology / MGI
abnormal brain morphology / MGI
abnormal brain commissure morphology / MGI
decreased lymph node number / MGI
abnormal lymph node morphology / MGI
abnormal dendritic cell physiology / MGI
abnormal macrophage physiology / MGI
abnormal male preputial gland morphology / MGI
short femur / MGI
dilated bile duct / MGI
intestinal/bowel diverticulum / MGI
bifid ureter / MGI
thymus atrophy / MGI
abnormal eye muscle morphology / MGI
abnormal hair follicle development / MGI
abnormal long bone morphology / MGI
abnormal Mullerian duct morphology / MGI
abnormal Wolffian duct morphology / MGI
absent molars / MGI
abnormal myocardium compact layer morphology / MGI
abnormal optic stalk morphology / MGI
abnormal optic cup morphology / MGI
absent stapedial artery / MGI
decreased length of long bones / MGI
abnormal osteoclast morphology / MGI
decreased bone resorption / MGI
absent spleen white pulp / MGI
decreased B cell proliferation / MGI
abnormal stapes morphology / MGI
absent guard hair / MGI
abnormal dendritic cell differentiation / MGI
decreased dendritic cell number / MGI
decreased immature B cell number / MGI
hypochromic anemia / MGI
abnormal osteoclast differentiation / MGI
decreased tumor necrosis factor secretion / MGI
decreased interleukin-12 secretion / MGI
decreased interleukin-6 secretion / MGI
decreased survivor rate / MGI
perimembraneous ventricular septal defect / MGI
muscular ventricular septal defect / MGI
persistent right dorsal aorta / MGI
herniated liver / MGI
postnatal lethality, complete penetrance / MGI
postnatal lethality, incomplete penetrance / MGI
perinatal lethality, incomplete penetrance / MGI
preweaning lethality, incomplete penetrance / MGI
umbilical vein stenosis / MGI
small perianal sebaceous gland / MGI
abnormal Meibomian gland development / MGI
thin hypoglossal nerve / MGI
ductus venosus stenosis / MGI
subcutaneous edema / MGI
absent ductus venosus valve / MGI
abnormal ductus venosus valve topology / MGI
persistent right 6th pharyngeal arch artery / MGI
abnormal endolymphatic sac topology / MGI
multiple persisting craniopharyngeal ducts / MGI
blood in lymph vessels / MGI
abnormal coronary sinus connection / MGI
abnormal vitelline vein topology / MGI
abnormal vertebral artery topology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Reporterless null allele (tm1d allele), service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6N-Atm1Brd Traf6tm2a(EUCOMM)Wtsi/WtsiOulu