IMPC phenotypes (gene matching)
B6.129-Prdm1tm2.1Liz/RobH
| Status | Available to order |
| EMMA ID | EM:08439 |
| Citation information | RRID:IMSR_EM:08439 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Prdm1tm2.1Liz/RobH |
| Alternative name | Prdm1 ΔEx1B/ΔEx1B(Rob) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Prdm1tm2.1Liz |
| Gene/Transgene symbol | Prdm1 |
Information from provider
| Provider | Elizabeth Robertson |
| Provider affiliation | The Sir William Dunn School of Pathology, University of Oxford |
| Genetic information | A targeted deletion of a 3.9kb fragment from Prdm1 (chromosome 10: 44,247,021 to 44,250,926) containing the transcript exon 1B, a novel alternative first exon that splices directly to exon 3. This deletion generated an exon 1B null allele. |
| Phenotypic information | Homozygous:Mice with targeted exon 1B deletion have slightly decreased expression in the yolk sac but show no other noticeable effects in embryo or adult tissues.Heterozygous:No phenotype. |
| Breeding history | Exact number of generations backcrossed is unknown, but is more than 10. Exact number of generations sib-mated is unknown, but is more than 10 as, after backcrossing, they were maintained by intercrossing. Currently maintained as homozygous stock. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (allele matching)
- immune system phenotype / MGI
MGI phenotypes (gene matching)
- double outlet right ventricle / MGI
- oligodactyly / MGI
- abnormal myotome development / MGI
- abnormal embryo development / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- abnormal placenta development / MGI
- decreased trophoblast giant cell number / MGI
- abnormal placenta labyrinth morphology / MGI
- hemorrhage / MGI
- no abnormal phenotype detected / MGI
- abnormal germ cell morphology / MGI
- abnormal aortic valve morphology / MGI
- abnormal pharyngeal arch morphology / MGI
- abnormal primordial germ cell migration / MGI
- no phenotypic analysis / MGI
- embryonic growth retardation / MGI
- right aortic arch / MGI
- abnormal dermomyotome development / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- abnormal dorsal aorta morphology / MGI
- absent oocytes / MGI
- decreased testis weight / MGI
- uterine hemorrhage / MGI
- azoospermia / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal third pharyngeal arch morphology / MGI
- absent second pharyngeal arch / MGI
- absent plasma cells / MGI
- decreased primordial germ cell number / MGI
- absent primordial germ cells / MGI
- abnormal splenocyte physiology / MGI
- atrioventricular septal defect / MGI
- vascular ring / MGI
- abnormal left subclavian artery morphology / MGI
- absent third pharyngeal arch / MGI
- postnatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- abnormal pharyngeal arch mesenchyme morphology / MGI
Literature references
- Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.;Morgan Marc A J, Magnusdottir Erna, Kuo Tracy C, Tunyaplin Chai, Harper James, Arnold Sebastian J, Calame Kathryn, Robertson Elizabeth J, Bikoff Elizabeth K, ;2009;Molecular and cellular biology;29;5813-27; 19737919