IMPC phenotypes (allele matching)
C57BL/6N-Pla2g10tm1b(EUCOMM)Hmgu/Ieg
| Status | Available to order |
| EMMA ID | EM:08414 |
| International strain name | C57BL/6N-Pla2g10tm1b(EUCOMM)Hmgu/Ieg |
| Alternative name | HEPD0539_1_A05 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Pla2g10tm1b(EUCOMM)Hmgu |
| Gene/Transgene symbol | Pla2g10 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0539_1_A05. For further details on the construction of this clone see the page at the IKMC page on the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sortm1(ACTB-cre,-EGFP)Ics (MGI:5285392)). Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTacUSA, wild-type C57BL/6NTacUSA |
| Stage of embryos | 2-cell |
Disease and phenotype information
IMPC phenotypes (gene matching)
- abnormal lens morphology / IMPC
- abnormal QT variability / IMPC
- decreased mature B cell number / IMPC
- decreased grip strength / IMPC
- abnormal heart morphology / IMPC
- cataract / IMPC
- prolonged QT interval / IMPC
- decreased heart rate / IMPC
- increased heart rate variability / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- prolonged RR interval / IMPC
- cardiovascular system phenotype / IMPC
MGI phenotypes (gene matching)
- decreased neutrophil cell number / MGI
- hypersecretion of corticosterone / MGI
- increased circulating corticosterone level / MGI
- decreased inflammatory response / MGI
- abnormal neutrophil physiology / MGI
- decreased IgE level / MGI
- abnormal cardiac muscle contractility / MGI
- decreased myocardial infarction size / MGI
- abnormal male reproductive system physiology / MGI
- altered response of heart to induced stress / MGI
- decreased eosinophil cell number / MGI
- decreased T cell number / MGI
- immune system phenotype / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- impaired neutrophil chemotaxis / MGI
- abnormal interleukin level / MGI
- abnormal prostaglandin level / MGI