C57BL/6N-Tacr1tm1b(EUCOMM)Wtsi/Cnrm

Status

Available to order

EMMA IDEM:08402
International strain nameC57BL/6N-Tacr1tm1b(EUCOMM)Wtsi/Cnrm
Alternative nameEPD0795_1_H02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTacr1tm1b(EUCOMM)Wtsi
Gene/Transgene symbolTacr1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider CNR, Consiglio Nazionale delle Ricerche
Provider affiliationEMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0795_1_H02. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sortm1(ACTB-cre,-EGFP)Ics (MGI:5285392)). Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased anxiety-related response / MGI
  • hyperactivity / MGI
  • impaired coordination / MGI
  • abnormal body temperature homeostasis / MGI
  • abnormal humoral immune response / MGI
  • decreased inflammatory response / MGI
  • abnormal dopamine level / MGI
  • increased airway responsiveness / MGI
  • abnormal touch/ nociception / MGI
  • abnormal pain threshold / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal respiratory mucosa goblet cell morphology / MGI
  • abnormal mast cell physiology / MGI
  • decreased circulating corticosterone level / MGI
  • abnormal chemical nociception / MGI
  • abnormal nociception after inflammation / MGI
  • joint inflammation / MGI
  • decreased vascular permeability / MGI
  • decreased nerve fiber response intensity / MGI
  • abnormal nervous system physiology / MGI
  • abnormal thermosensation / MGI
  • abnormal noradrenaline level / MGI
  • abnormal neuron physiology / MGI
  • hyperalgesia / MGI
  • hyporesponsive to tactile stimuli / MGI
  • decreased aggression / MGI
  • increased chemical nociceptive threshold / MGI
  • abnormal physiological response to xenobiotic / MGI
  • impaired conditioned place preference behavior / MGI
  • impaired behavioral response to xenobiotic / MGI
  • impaired behavioral response to addictive substance / MGI
  • impaired behavioral response to morphine / MGI
  • decreased vocalization / MGI
  • abnormal pulmonary respiratory rate response / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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