C57BL/6N-Pdgfrbtm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:08382
International strain nameC57BL/6N-Pdgfrbtm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0676_4_F11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolPdgfrbtm1a(EUCOMM)Hmgu
Gene/Transgene symbolPdgfrb
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0676_4_F11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • enlarged heart / IMPC
  • decreased circulating fructosamine level / IMPC
  • increased circulating triglyceride level / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal angiogenesis / MGI
  • abnormal heart morphology / MGI
  • overriding aortic valve / MGI
  • enlarged heart / MGI
  • double outlet right ventricle / MGI
  • schistocytosis / MGI
  • short snout / MGI
  • abnormal pulmonary artery morphology / MGI
  • abnormal kidney blood vessel morphology / MGI
  • kidney hemorrhage / MGI
  • decreased body size / MGI
  • anemia / MGI
  • abnormal blood vessel morphology / MGI
  • thymus hypoplasia / MGI
  • hemorrhage / MGI
  • intracranial hemorrhage / MGI
  • perinatal lethality / MGI
  • abnormal eye morphology / MGI
  • abnormal kidney physiology / MGI
  • no abnormal phenotype detected / MGI
  • disorganized myocardium / MGI
  • hydrops fetalis / MGI
  • abnormal erythrocyte morphology / MGI
  • micrognathia / MGI
  • anisocytosis / MGI
  • poikilocytosis / MGI
  • dilated heart right ventricle / MGI
  • abnormal retinal vasculature morphology / MGI
  • increased vascular permeability / MGI
  • retinal detachment / MGI
  • dilated heart atrium / MGI
  • cardiac fibrosis / MGI
  • thrombocytopenia / MGI
  • abnormal placenta vasculature / MGI
  • abnormal embryonic hematopoiesis / MGI
  • kidney cysts / MGI
  • pallor / MGI
  • abnormal pericyte morphology / MGI
  • abnormal retinal layer morphology / MGI
  • abnormal heart left ventricle morphology / MGI
  • abnormal venule morphology / MGI
  • right aortic arch / MGI
  • abnormal basement membrane morphology / MGI
  • abnormal trophoblast layer morphology / MGI
  • polychromatophilia / MGI
  • increased susceptibility to injury / MGI
  • glomerulosclerosis / MGI
  • abnormal renal glomerulus morphology / MGI
  • abnormal mesangial cell morphology / MGI
  • renal/urinary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • cardiovascular system phenotype / MGI
  • vision/eye phenotype / MGI
  • decreased angiogenesis / MGI
  • abnormal vascular endothelial cell morphology / MGI
  • increased vascular endothelial cell number / MGI
  • retinal hemorrhage / MGI
  • eye hemorrhage / MGI
  • clinodactyly / MGI
  • decreased retinal ganglion cell number / MGI
  • retinal ganglion cell degeneration / MGI
  • absent podocytes / MGI
  • increased heart ventricle size / MGI
  • abnormal placental labyrinth vasculature morphology / MGI
  • petechiae / MGI
  • increased nucleated erythrocyte cell number / MGI
  • eye opacity / MGI
  • abnormal retinal blood vessel morphology / MGI
  • abnormal retinal blood vessel pattern / MGI
  • ventricular septal defect / MGI
  • atrioventricular septal defect / MGI
  • perimembraneous ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • kidney microaneurysm / MGI
  • vascular ring / MGI
  • abnormal left subclavian artery morphology / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • decreased glomerular capillary number / MGI
  • absent mesangial cell / MGI
  • glomerulus hemorrhage / MGI
  • decreased kidney cell proliferation / MGI
  • glomerular capillary thrombosis / MGI
  • skin hemorrhage / MGI
  • purpura / MGI
  • decreased fibroblast proliferation / MGI
  • abnormal fibroblast migration / MGI
  • decreased fibroblast apoptosis / MGI
  • abnormal blood-retinal barrier function / MGI
  • increased retinal apoptosis / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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Legally binding conditions for the transfer

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