| Status | Available to order |
| EMMA ID | EM:08367 |
| Citation information | RRID:IMSR_EM:08367 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Mogtm1(cre)Gkl/Flmg |
| Alternative name | B6-Mog |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Mogtm1(cre)Gkl |
| Gene/Transgene symbol | Mog |
| Provider | George Kollias |
| Provider affiliation | BSRC Al. Fleming |
| Genetic information | The open reading frame of the Cre recombinase gene, followed by the human growth hormone polyadenylation signal and the neomycin resistance gene, has replaced all except the 5'-most segment of the first exon, the first intron and all but the 3'-most part of the second exon of the myelin oligodendrocyte glycoprotein gene, thus targeting Cre expression to oligodendrocytes (ODCs). Western blot analysis demonstrated that wild-type MOG protein is present in heterozygous and wild-type brains at comparable levels, but is not detectable in homozygous mutant brain. |
| Phenotypic information | Homozygous:Cre expression in oligodendrocytesHeterozygous:Cre expression in oligodendrocytes |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous CBA x C57BL/6 males |
