C57BL/6-Dclre1cm1Brck/Flmg

Status

Available to order

EMMA IDEM:08361
International strain nameC57BL/6-Dclre1cm1Brck/Flmg
Alternative nameDclre1c
Strain typeSpontaneous
Allele/Transgene symbolDclre1cm1Brck
Gene/Transgene symbolDclre1c

Information from provider

ProviderThomas Brocker
Provider affiliationInstitute for Immunology, Ludwig-Maximilians-Universität Munich
Genetic informationGenomic deletion of 4035 base pairs in Dclre1c including exons 10 and 11 of this gene.
Phenotypic informationHomozygous:
Non leaky absence of B and T cells in the presence of NK cells.

Heterozygous:
no phenotype observed
References
  • Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency.;Barthels Christian, Puchałka Jacek, Racek Tomas, Klein Christoph, Brocker Thomas, ;2013;PloS one;8;e74838; 24069355
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archivinghomozygous C57BL/6, wild-type C57BL/6J
Stage of embryosMorula

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • absent T cells / MGI
  • absent B cells / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • decreased double-positive T cell number / MGI
  • immune system phenotype / MGI
  • decreased pre-B cell number / MGI
  • decreased DN1 thymic pro-T cell number / MGI
  • decreased DN4 thymocyte number / MGI
MGI phenotypes (gene matching)
  • increased neutrophil cell number / MGI
  • small spleen / MGI
  • spleen hypoplasia / MGI
  • decreased thymocyte number / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • increased body weight / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • arrested B cell differentiation / MGI
  • decreased IgM level / MGI
  • arrested T cell differentiation / MGI
  • increased cellular sensitivity to gamma-irradiation / MGI
  • abnormal B cell differentiation / MGI
  • small lymph nodes / MGI
  • abnormal lymph node morphology / MGI
  • abnormal leukocyte physiology / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • induced chromosome breakage / MGI
  • increased cellular sensitivity to ionizing radiation / MGI
  • decreased thymus weight / MGI
  • decreased B-1 B cell number / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • decreased T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased B cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • increased macrophage cell number / MGI
  • abnormal cell physiology / MGI
  • decreased systemic arterial systolic blood pressure / MGI
  • decreased NK T cell number / MGI
  • increased NK cell number / MGI
  • absent T cells / MGI
  • absent B cells / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • increased pro-B cell number / MGI
  • decreased pre-B cell number / MGI
  • decreased mature B cell number / MGI
  • absent immature B cells / MGI
  • abnormal mononuclear cell morphology / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • abnormal T cell receptor V(D)J recombination / MGI
  • abnormal T cell receptor beta chain V(D)J recombination / MGI
  • abnormal immunoglobulin heavy chain V(D)J recombination / MGI
  • chromosomal instability / MGI
  • decreased splenocyte number / MGI
  • decreased DN1 thymic pro-T cell number / MGI
  • decreased DN4 thymocyte number / MGI
  • absent thymus cortex / MGI
  • increased central memory CD4-positive, alpha-beta T cell number / MGI
  • increased effector memory CD4-positive, alpha-beta T cell number / MGI
  • increased central memory CD8 positive, alpha-beta T cell number / MGI
  • increased effector memory CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, naive alpha-beta T cell number / MGI
  • decreased response to antigen / MGI
  • impaired humoral immune response / MGI

Literature references

  • Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency.;Barthels Christian, Puchałka Jacek, Racek Tomas, Klein Christoph, Brocker Thomas, ;2013;PloS one;8;e74838; 24069355

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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