- absent T cells / MGI
- absent B cells / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- absent CD4-positive, alpha beta T cells / MGI
- decreased double-positive T cell number / MGI
- immune system phenotype / MGI
- decreased pre-B cell number / MGI
- decreased DN1 thymic pro-T cell number / MGI
- decreased DN4 thymocyte number / MGI
C57BL/6-Dclre1cm1Brck/Flmg
Status | Available to order |
EMMA ID | EM:08361 |
Citation information | RRID:IMSR_EM:08361 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6-Dclre1cm1Brck/Flmg |
Alternative name | Dclre1c |
Strain type | Spontaneous |
Allele/Transgene symbol | Dclre1cm1Brck |
Gene/Transgene symbol | Dclre1c |
Information from provider
Provider | Thomas Brocker |
Provider affiliation | Institute for Immunology, Ludwig-Maximilians-Universität Munich |
Genetic information | Genomic deletion of 4035 base pairs in Dclre1c including exons 10 and 11 of this gene. |
Phenotypic information | Homozygous:Non leaky absence of B and T cells in the presence of NK cells.Heterozygous:no phenotype observed |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | yes |
Information from EMMA
Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Animals used for archiving | homozygous C57BL/6 males, wild-type C57BL/6J females |
Stage of embryos | Morula |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Severe combined immunodeficiency due to DCLRE1C deficiency / Orphanet_275
- Omenn syndrome / Orphanet_39041
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- increased neutrophil cell number / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- decreased thymocyte number / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- increased body weight / MGI
- decreased body weight / MGI
- decreased body size / MGI
- arrested B cell differentiation / MGI
- decreased IgM level / MGI
- arrested T cell differentiation / MGI
- increased cellular sensitivity to gamma-irradiation / MGI
- abnormal B cell differentiation / MGI
- small lymph nodes / MGI
- abnormal lymph node morphology / MGI
- abnormal leukocyte physiology / MGI
- absent CD4-positive, alpha beta T cells / MGI
- induced chromosome breakage / MGI
- increased cellular sensitivity to ionizing radiation / MGI
- decreased thymus weight / MGI
- decreased B-1 B cell number / MGI
- decreased lymphocyte cell number / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- decreased double-positive T cell number / MGI
- decreased B cell proliferation / MGI
- decreased T cell proliferation / MGI
- immune system phenotype / MGI
- increased macrophage cell number / MGI
- abnormal cell physiology / MGI
- decreased systemic arterial systolic blood pressure / MGI
- decreased NK T cell number / MGI
- increased NK cell number / MGI
- absent T cells / MGI
- absent B cells / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased single-positive T cell number / MGI
- increased pro-B cell number / MGI
- decreased pre-B cell number / MGI
- decreased mature B cell number / MGI
- absent immature B cells / MGI
- abnormal mononuclear cell morphology / MGI
- abnormal spleen B cell follicle morphology / MGI
- abnormal T cell receptor V(D)J recombination / MGI
- abnormal T cell receptor beta chain V(D)J recombination / MGI
- abnormal immunoglobulin heavy chain V(D)J recombination / MGI
- chromosomal instability / MGI
- decreased splenocyte number / MGI
- decreased DN1 thymic pro-T cell number / MGI
- decreased DN4 thymocyte number / MGI
- absent thymus cortex / MGI
- increased central memory CD4-positive, alpha-beta T cell number / MGI
- increased effector memory CD4-positive, alpha-beta T cell number / MGI
- increased central memory CD8 positive, alpha-beta T cell number / MGI
- increased effector memory CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, naive alpha-beta T cell number / MGI
- decreased response to antigen / MGI
- impaired humoral immune response / MGI
Literature references
- Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency.;Barthels Christian, Puchałka Jacek, Racek Tomas, Klein Christoph, Brocker Thomas, ;2013;PloS one;8;e74838; 24069355
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