B6;129-Flrt2tm1c(EUCOMM)Wtsi/RobH

Status

Available to order

EMMA IDEM:08315
International strain nameB6;129-Flrt2tm1c(EUCOMM)Wtsi/RobH
Alternative nameFlrt2 tm1c (EUCOMM) wtsi
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolFlrt2tm1c(EUCOMM)Wtsi
Gene/Transgene symbolFlrt2

Information from provider

ProviderElizabeth Robertson
Provider affiliationSir William Dunn School of Pathology, University of Oxford
Genetic informationFloxed conditional allele for Flrt2 derived from the Flrt2 EUCOMM knock-out first mutation vector (EUCOMM ID:69623). Exposure of vector to flp recombinase excised the L1L2_Bact-P cassette (containing a LacZ sequence and neomycin under the control of human beta-actin promoter SV40) generating an allele with the Flrt2 coding exon flanked by loxP sites.
Phenotypic informationHomozygous:
Homozygous floxed mice have no phenotype.

Heterozygous:
Heterozygous floxed mice have no phenotype.
Breeding historyMice with the original Flrt2 EUCOMM knock-out first mutation vector were crossed with mice with flp recombinase. This generated mice heterozygous for the Flrt2 conditional allele. Heterozygous mice for the Flrt2 conditional allele were intercrossed to generate mice homozygous for the Flrt2 conditional allele. The strain has since been maintained as a homozygous line.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (gene matching)
  • pericardial edema / MGI
  • hemorrhage / MGI
  • abnormal epicardium morphology / MGI
  • nervous system phenotype / MGI
  • abnormal endocardium morphology / MGI
  • embryo phenotype / MGI
  • abnormal neuronal migration / MGI
  • ventricular myocardium compact layer hypoplasia / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI

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Practical information

Example health report
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Material Transfer Agreement (MTA)
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