C57BL/6-Tg(Mt1-Mecr)#Jkh/Oulu
| Status | Available to order |
| EMMA ID | EM:08310 |
| International strain name | C57BL/6-Tg(Mt1-Mecr)#Jkh/Oulu |
| Alternative name | Mecr |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Mt1-Mecr)#Jkh |
| Gene/Transgene symbol | Tg(Mt1-Mecr)#Jkh |
Information from provider
| Provider | Kalervo Hiltunen |
| Provider affiliation | Faculty of Biochemistry and Molecular Medicine , University of Oulu |
| Genetic information | Transgenic mouse overexpressing Mecr gene under control of metallothionein-1 promoter. |
| Phenotypic information | Homozygous:Cardiac abnormalities like focal mitochondrial clumping in myocardium, decreased cardiac mechanical function and decreased performance in the endurance tolerance test.Heterozygous:--- |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd, wild-type 0 |
| Stage of embryos | Morula |
Literature references
- Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse.;Chen Zhijun, Leskinen Hanna, Liimatta Erkki, Sormunen Raija T, Miinalainen Ilkka J, Hassinen Ilmo E, Hiltunen J Kalervo, ;2009;PloS one;4;e5589; 19440339