C57BL/6-Tg(Mt1-Mecr)#Jkh/Oulu
| Status | Available to order |
| EMMA ID | EM:08310 |
| Citation information | RRID:IMSR_EM:08310 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tg(Mt1-Mecr)#Jkh/Oulu |
| Alternative name | Mecr |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Mt1-Mecr)#Jkh |
| Gene/Transgene symbol | Tg(Mt1-Mecr)#Jkh |
Information from provider
| Provider | Kalervo Hiltunen |
| Provider affiliation | Faculty of Biochemistry and Molecular Medicine , University of Oulu |
| Genetic information | Transgenic mouse overexpressing Mecr gene under control of metallothionein-1 promoter. |
| Phenotypic information | Homozygous:Cardiac abnormalities like focal mitochondrial clumping in myocardium, decreased cardiac mechanical function and decreased performance in the endurance tolerance test.Heterozygous:--- |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd males, wild-type females |
| Stage of embryos | Morula |
Literature references
- Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse.;Chen Zhijun, Leskinen Hanna, Liimatta Erkki, Sormunen Raija T, Miinalainen Ilkka J, Hassinen Ilmo E, Hiltunen J Kalervo, ;2009;PloS one;4;e5589; 19440339