IMPC phenotypes (gene matching)
B6NJ;B6N-Cbltm1a(EUCOMM)Hmgu/CipheOrl
| Status | Available to order |
| EMMA ID | EM:08308 |
| International strain name | B6NJ;B6N-Cbltm1a(EUCOMM)Hmgu/CipheOrl |
| Alternative name | HEPD0672_6_B06 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Cbltm1a(EUCOMM)Hmgu |
| Gene/Transgene symbol | Cbl |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Centre d'ImmunoPhenomique - Ciphe |
| Provider affiliation | Centre d'ImmunoPhenomique - Ciphe |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0672_6_B06. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Aggressive systemic mastocytosis / Orphanet_98850
- Noonan syndrome / Orphanet_648
- Noonan syndrome-like disorder with juvenile myelomonocytic leukemia / Orphanet_363972
MGI phenotypes (gene matching)
- extramedullary hematopoiesis / MGI
- abnormal branching of the mammary ductal tree / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- enlarged lymph nodes / MGI
- abnormal thymus morphology / MGI
- dilated uterus / MGI
- increased body weight / MGI
- decreased body weight / MGI
- hyperactivity / MGI
- polyphagia / MGI
- decreased brown adipose tissue amount / MGI
- decreased white adipose tissue amount / MGI
- thymus hypoplasia / MGI
- abnormal T cell activation / MGI
- abnormal glucose homeostasis / MGI
- postnatal lethality / MGI
- abnormal muscle physiology / MGI
- abnormal lipid homeostasis / MGI
- abnormal T cell differentiation / MGI
- abnormal thymus size / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal myeloblast morphology/development / MGI
- abnormal T cell physiology / MGI
- decreased circulating triglyceride level / MGI
- decreased circulating free fatty acid level / MGI
- decreased circulating insulin level / MGI
- increased insulin sensitivity / MGI
- abnormal gas homeostasis / MGI
- increased lean body mass / MGI
- increased hematopoietic stem cell number / MGI
- increased oxygen consumption / MGI
- improved glucose tolerance / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- skeleton phenotype / MGI
- darkened coat color / MGI
- abnormal food intake / MGI
- thrombocytosis / MGI
- increased body temperature / MGI
- abnormal enzyme/coenzyme activity / MGI
- increased susceptibility to diet-induced obesity / MGI
- decreased susceptibility to diet-induced obesity / MGI
- decreased circulating leptin level / MGI
- abnormal epididymal fat pad morphology / MGI
- decreased single-positive T cell number / MGI
- increased spleen red pulp amount / MGI
- abnormal splenic cell ratio / MGI
- abnormal thymus cell ratio / MGI
- abnormal lymph node cell ratio / MGI
- abnormal mammary fat pad morphology / MGI
- dilated oviduct / MGI
- abnormal fat cell morphology / MGI
- decreased liver triglyceride level / MGI
- abnormal foot pigmentation / MGI
- decreased total body fat amount / MGI
- myeloid hyperplasia / MGI
- decreased respiratory quotient / MGI
- neonatal lethality, incomplete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- increased tail pigmentation / MGI
- increased ear pigmentation / MGI
- increased mitochondria size / MGI
- increased muscle cell glucose uptake / MGI