| Status | Available to order |
| EMMA ID | EM:08305 |
| International strain name | B6.129-Amacrtm1Jkh/Oulu |
| Alternative name | Amacr |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Amacrtm1Jkh |
| Gene/Transgene symbol | Amacr |
| Provider | Kalervo Hiltunen |
| Provider affiliation | Faculty of Biochemistry and Molecular Medicine, University of Oulu |
| Genetic information | Exons 1-3 and introns 1-2 of Amacr gene are replaced with the neomycin-resistance gene by homologous recombination. |
| Phenotypic information | Homozygous:No clinical phenotype on standard laboratory conditions, lack of mature bile acids and accumulation of bile acid intermediates. On phytol enriched diet mice develop liver failure and death.Heterozygous:No phenotype on heterozygous mice. |
| Breeding history | 10 backcrosses to C57BL/6 |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | homozygous C57BL/6JOlaHsd, wild-type C57BL/6JOlaHsd |
| Stage of embryos | 2-cell |
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
