C57BL/6-Mecrtm1(fabI)Akast/Oulu
Status | Available to order |
EMMA ID | EM:08290 |
International strain name | C57BL/6-Mecrtm1(fabI)Akast/Oulu |
Alternative name | C57BL/6-Mecrtm(fabI)/UofO |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Mecrtm1(fabI)Akast |
Gene/Transgene symbol | Mecr |
Information from provider
Provider | Alexander Kastaniotis |
Provider affiliation | Faculty of Biochemistry and Molecular Medicine, University of Oulu |
Genetic information | In-frame fusion of E. coli fabI to the first 54 nucleotides of Mecr (mouse mitochondrial enoyl reductase) exon 2, generating an ORF encoding double HA-tagged bacterial fabI enoyl reductase fused to the Mecr mitochondrial targeting sequence. The fabI ORF is followed by a strong transcriptional terminator (BGH) and the neomycin resistance cassette and transcriptional terminator from loxP-FRT-PGK-gb2-neo-FRT (Gene Bridges). The neo cassette can be removed using the FRT sites. |
Phenotypic information | Homozygous:Embryonic lethal at E10-11.Heterozygous:No detectable phenotype |
Breeding history | ES cells and blastocysts both from C57BL/6. Chimeras were bred with C57BL/6OlaHsd females. |
References | None available |
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | University of Oulu, Oulu, Finland |
Animals used for archiving | heterozygous C57BL/6JOlaHsd, wild-type C57BL/6JOlaHsd |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- MEPAN syndrome / Orphanet_508093
IMPC phenotypes (gene matching)
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