C57BL/6N-Dicer1^{tm1a(EUCOMM)Wtsi}/H

Status	Available to order
EMMA ID	EM:08289
International strain name	C57BL/6N-Dicer1^{tm1a(EUCOMM)Wtsi}/H
Alternative name	EPD0597_3_H11
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Dicer1^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Dicer1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from EUCOMM ES clone EPD0597_3_H11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Orphanet associated rare diseases, based on orthologous gene matching

Global developmental delay-lung cysts-overgrowth-Wilms tumor syndrome / Orphanet_404476
Pleuropulmonary blastoma familial tumor susceptibility syndrome / Orphanet_284343
Embryonal rhabdomyosarcoma / Orphanet_99757

IMPC phenotypes (gene matching)

MGI phenotypes (gene matching)

abnormal angiogenesis / MGI
small liver / MGI
abnormal blood vessel morphology / MGI
abnormal embryo development / MGI
decreased embryo size / MGI
absent vitelline blood vessels / MGI
embryonic growth arrest / MGI
female infertility / MGI
no abnormal phenotype detected / MGI
decreased susceptibility to viral infection / MGI
increased susceptibility to viral infection / MGI
no phenotypic analysis / MGI
abnormal vitelline vascular remodeling / MGI
increased B-1 B cell number / MGI
decreased T cell number / MGI
abnormal female meiosis / MGI
reproductive system phenotype / MGI
decreased CD4-positive, alpha beta T cell number / MGI
decreased CD8-positive, alpha-beta T cell number / MGI
decreased single-positive T cell number / MGI
abnormal meiotic spindle morphology / MGI
increased effector memory CD4-positive, alpha-beta T cell number / MGI
increased central memory CD8 positive, alpha-beta T cell number / MGI
increased effector memory CD8-positive, alpha-beta T cell number / MGI
perinatal lethality, incomplete penetrance / MGI
embryonic lethality between implantation and somite formation, complete penetrance / MGI
lethality throughout fetal growth and development, complete penetrance / MGI
embryonic lethality during organogenesis, incomplete penetrance / MGI
decreased CD8-positive, naive alpha-beta T cell number / MGI

Information from provider