C57BL/6J-Tg(Nos2-tdTomato,-cre)1Albe/Orl
| Status | Available to order |
| EMMA ID | EM:08262 |
| Citation information | RRID:IMSR_EM:08262 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6J-Tg(Nos2-tdTomato,-cre)1Albe/Orl |
| Alternative name | NOS2-Tomato-Cre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Nos2-tdTomato,-cre)1Albe |
| Gene/Transgene symbol | Tg(Nos2-tdTomato,-cre)1Albe |
Information from provider
| Provider | Bessis Bessis |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Additional owner | Grégoire Lauvau, Albert Einstein College of Medecine, New York, U.S.A. and Frédéric Geissmann, King's College, London, UK |
| Genetic information | A tdTomato-ires-Cre cassette was inserted by homologous recombination into the RP23-341J22 bacterial artificial chromosome (BAC). The cassette was inserted into exon 2 with the ATG of the tdTomato replacing the endogenous ATG. The recombined BAC was then used to generate the transgenic mouse. |
| Phenotypic information | Homozygous:Express the tdTomato and cre recombinase in Nos2-positive cells.Heterozygous:Express the tdTomato and cre recombinase in Nos2-positive cells |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J males |
Literature references
- NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation.;Béchade Catherine, Colasse Sabrina, Diana Marco A, Rouault Martin, Bessis Alain, ;2014;Glia;62;956-63; 24615726
- Myeloid cell plasticity in the evolution of central nervous system autoimmunity.;Giles David A, Washnock-Schmid Jesse M, Duncker Patrick C, Dahlawi Somiah, Ponath Gerald, Pitt David, Segal Benjamin M, ;2018;Annals of neurology;83;131-141; 29283442