C57BL/6J-Tg(Nos2-tdTomato,-cre)1Albe/Orl
| Status | Available to order |
| EMMA ID | EM:08262 |
| International strain name | C57BL/6J-Tg(Nos2-tdTomato,-cre)1Albe/Orl |
| Alternative name | NOS2-Tomato-Cre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Nos2-tdTomato,-cre)1Albe |
| Gene/Transgene symbol | Tg(Nos2-tdTomato,-cre)1Albe |
Information from provider
| Provider | Bessis Bessis |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Additional owner | Grégoire Lauvau, Albert Einstein College of Medecine, New York, U.S.A. and Frédéric Geissmann, King's College, London, UK |
| Genetic information | A tdTomato-ires-Cre cassette was inserted by homologous recombination into the RP23-341J22 bacterial artificial chromosome (BAC). The cassette was inserted into exon 2 with the ATG of the tdTomato replacing the endogenous ATG. The recombined BAC was then used to generate the transgenic mouse. |
| Phenotypic information | Homozygous:Express the tdTomato and cre recombinase in Nos2-positive cells.Heterozygous:Express the tdTomato and cre recombinase in Nos2-positive cells |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J |
Literature references
- NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation.;Béchade Catherine, Colasse Sabrina, Diana Marco A, Rouault Martin, Bessis Alain, ;2014;Glia;62;956-63; 24615726
- Myeloid cell plasticity in the evolution of central nervous system autoimmunity.;Giles David A, Washnock-Schmid Jesse M, Duncker Patrick C, Dahlawi Somiah, Ponath Gerald, Pitt David, Segal Benjamin M, ;2018;Annals of neurology;83;131-141; 29283442