C57BL/6N-Col9a2tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:08189
Citation informationRRID:IMSR_EM:08189 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Col9a2tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0774_3_F03
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCol9a2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolCol9a2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0774_3_F03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • tremors / IMPC
  • abnormal femur morphology / IMPC
  • abnormal joint morphology / IMPC
  • abnormal humerus morphology / IMPC
  • abnormal tibia morphology / IMPC
  • abnormal auditory brainstem response / IMPC
  • abnormal radius morphology / IMPC
  • decreased locomotor activity / IMPC
  • abnormal ear morphology / IMPC
  • decreased prepulse inhibition / IMPC
  • abnormal pelvic girdle bone morphology / IMPC
  • increased circulating triglyceride level / IMPC
  • abnormal ulna morphology / IMPC
  • short tibia / IMPC
  • increased circulating alkaline phosphatase level / IMPC

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
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