C.Cg-Tg(Ltf-icre)14Mmul/Biat

Status	Available to order
EMMA ID	EM:08182
Citation information	RRID:IMSR_EM:08182 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C.Cg-Tg(Ltf-icre)14Mmul/Biat
Alternative name	C.Cg-Tg(Ltf-Cre)14
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Ltf-icre)14Mmul
Gene/Transgene symbol	Tg(Ltf-icre)14Mmul

Information from provider

Provider	Mathias Müller
Provider affiliation	Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
Additional owner	Boris Kovacic, Meduni Wien, Institut fuer Medizinische Genetik, Vienna, Austria
Genetic information	A cassette containing the iCre recombinase, an artificial intron, a bovine growth hormone polyadenylation signal and an ampicillin-resistance gene flanked by Frt (Flp recombinase target) sites, was recombined into the first exon of the Ltf gene. To delete the ampicillin gene, a plasmid expressing the FLP recombinase was transformed into E.coli harboring the recombined BAC. Correct insertion and ampR-gene deletion were verified by Southern blotting and by DNA sequencing. BAC was purified using a CsCl gradient and ultracentrifugation and injected into the pro-nuclei of (B6 x 129/Sv)F1 oocytes.
Phenotypic information	Homozygous: no phenotype Heterozygous: no phenotype
References	Lactotransferrin-Cre reporter mice trace neutrophils, monocytes/macrophages and distinct subtypes of dendritic cells.;Kovacic Boris, Hoelbl-Kovacic Andrea, Fischhuber Katrin M, Leitner Nicole R, Gotthardt Dagmar, Casanova Emilio, Sexl Veronika, Müller Mathias, ;2014;Haematologica;99;1006-15; 24561791
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria
Animals used for archiving	heterozygous BALB/c males

Literature references

Lactotransferrin-Cre reporter mice trace neutrophils, monocytes/macrophages and distinct subtypes of dendritic cells.;Kovacic Boris, Hoelbl-Kovacic Andrea, Fischhuber Katrin M, Leitner Nicole R, Gotthardt Dagmar, Casanova Emilio, Sexl Veronika, Müller Mathias, ;2014;Haematologica;99;1006-15; 24561791

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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