C57BL/6NTac-Fgf2tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:08180
Citation informationRRID:IMSR_EM:08180 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Fgf2tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0215_2_A08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolFgf2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolFgf2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0215_2_A08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating serum albumin level / IMPC
  • limb grasping / IMPC
  • abnormal retina morphology / IMPC
  • increased circulating total protein level / IMPC
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • altered response to myocardial infarction / MGI
  • abnormal cerebral cortex morphology / MGI
  • thickened cerebral cortex / MGI
  • abnormal stratification in cerebral cortex / MGI
  • abnormal frontal lobe morphology / MGI
  • abnormal sleep pattern / MGI
  • hypotension / MGI
  • abnormal bone marrow morphology / MGI
  • abnormal myeloblast morphology/development / MGI
  • abnormal neuron morphology / MGI
  • delayed wound healing / MGI
  • decreased vasoconstriction / MGI
  • increased myocardial infarction size / MGI
  • increased cardiomyocyte apoptosis / MGI
  • loss of cortex neurons / MGI
  • loss of glutamate neurons / MGI
  • abnormal vascular endothelial cell migration / MGI
  • decreased left ventricle systolic pressure / MGI
  • decreased left ventricle developed pressure / MGI
  • abnormal cardiac muscle relaxation / MGI
  • abnormal baroreceptor physiology / MGI
  • decreased mean systemic arterial blood pressure / MGI
  • decreased cardiac muscle contractility / MGI
  • muscle phenotype / MGI
  • hearing/vestibular/ear phenotype / MGI
  • cardiovascular system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • reproductive system phenotype / MGI
  • vision/eye phenotype / MGI
  • thrombocytosis / MGI
  • abnormal neuronal migration / MGI
  • thin cerebral cortex / MGI
  • abnormal common myeloid progenitor cell morphology / MGI
  • abnormal hippocampal commissure morphology / MGI
  • abnormal spinal cord grey matter morphology / MGI
  • abnormal neuron differentiation / MGI
  • abnormal cerebral cortex pyramidal cell morphology / MGI
  • decreased cerebral cortex pyramidal cell number / MGI
  • decreased bone mineral content / MGI
  • mortality/aging / MGI

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Practical information

Genotyping protocol

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