IMPC phenotypes (allele matching)
C57BL/6N-Roratm1b(EUCOMM)Wtsi/Ieg
| Status | Available to order |
| EMMA ID | EM:08085 |
| International strain name | C57BL/6N-Roratm1b(EUCOMM)Wtsi/Ieg |
| Alternative name | EPD0157_5_B01 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Roratm1b(EUCOMM)Wtsi |
| Gene/Transgene symbol | Rora |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0157_5_B01. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sor |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTacUSA |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased circulating HDL cholesterol level / MGI
- abnormal vasoconstriction / MGI
- absent duvet hair / MGI
- sparse hair / MGI
- retarded hair growth / MGI
- tremors / MGI
- hindlimb paralysis / MGI
- abnormal olfactory bulb morphology / MGI
- abnormal cerebellum morphology / MGI
- small cerebellum / MGI
- abnormal cerebellar foliation / MGI
- abnormal cerebellum external granule cell layer morphology / MGI
- abnormal cerebellar Purkinje cell layer / MGI
- Purkinje cell degeneration / MGI
- abnormal Purkinje cell morphology / MGI
- decreased Purkinje cell number / MGI
- delaminated Purkinje cell layer / MGI
- ectopic Purkinje cell / MGI
- abnormal cerebellar granule layer morphology / MGI
- absent cerebellar granule layer / MGI
- abnormal cerebellar molecular layer / MGI
- thin cerebellar molecular layer / MGI
- decreased body size / MGI
- abnormal maternal nurturing / MGI
- ataxia / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- abnormal spatial learning / MGI
- limb grasping / MGI
- impaired righting response / MGI
- impaired limb coordination / MGI
- impaired balance / MGI
- abnormal vasodilation / MGI
- abnormal immune system physiology / MGI
- lung inflammation / MGI
- reduced female fertility / MGI
- abnormal estrous cycle / MGI
- abnormal olfaction / MGI
- abnormal motor capabilities/coordination/movement / MGI
- abnormal lipid homeostasis / MGI
- abnormal brain morphology / MGI
- abnormal fertility/fecundity / MGI
- abnormal respiratory mucosa morphology / MGI
- abnormal lung compliance / MGI
- abnormal macrophage physiology / MGI
- increased IgE level / MGI
- abnormal sexual interaction / MGI
- abnormal immune system organ morphology / MGI
- small olfactory bulb / MGI
- ectopic cerebellar granule cells / MGI
- abnormal motor learning / MGI
- abnormal excitatory postsynaptic currents / MGI
- no phenotypic analysis / MGI
- abnormal external female genitalia morphology / MGI
- abnormal nervous system physiology / MGI
- spleen atrophy / MGI
- thymus atrophy / MGI
- abnormal radial glial cell morphology / MGI
- abnormal inferior olivary complex morphology / MGI
- abnormal female reproductive system physiology / MGI
- abnormal hormone level / MGI
- abnormal cerebellar granule cell morphology / MGI
- abnormal brain interneuron morphology / MGI
- abnormal limb posture / MGI
- abnormal synaptic glutamate release / MGI
- decreased mean systemic arterial blood pressure / MGI
- decreased circulating cholesterol level / MGI
- atherosclerotic lesions / MGI
- increased susceptibility to atherosclerosis / MGI
- immune system phenotype / MGI
- taste/olfaction phenotype / MGI
- increased angiogenesis / MGI
- thin cerebellar granule layer / MGI
- abnormal Purkinje cell dendrite morphology / MGI
- abnormal Purkinje cell differentiation / MGI
- increased interleukin-1 secretion / MGI
- decreased cerebellar granule cell number / MGI
- delayed estrous cycle / MGI
- prolonged estrus / MGI
- prolonged metestrus / MGI
- reduced cerebellar foliation / MGI
- abnormal olfactory bulb granule cell morphology / MGI
- abnormal olfactory bulb layer morphology / MGI
- abnormal olfactory bulb external plexiform layer morphology / MGI
- abnormal olfactory bulb glomerular layer morphology / MGI
- abnormal olfactory bulb granule cell layer morphology / MGI
- abnormal olfactory bulb internal plexiform layer morphology / MGI
- abnormal olfactory bulb mitral cell layer morphology / MGI
- abnormal cerebellar layer morphology / MGI
- absent cerebellar granule cells / MGI
- abnormal neuron proliferation / MGI
- abnormal cerebellum deep nucleus morphology / MGI
- decreased grip strength / MGI
- abnormal olfactory bulb outer nerve layer morphology / MGI
- lethality at weaning, incomplete penetrance / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- abnormal cochlear VIII nucleus morphology / MGI
- increased noradrenaline level / MGI
- decreased cerebellar granule cell precursor proliferation / MGI
- decreased taurine level / MGI
- decreased gamma-aminobutyric acid level / MGI
- decreased aspartic acid level / MGI