IMPC phenotypes (allele matching)
C57BL/6N-Entpd1tm1b(EUCOMM)Wtsi/Ieg
| Status | Available to order |
| EMMA ID | EM:08058 |
| International strain name | C57BL/6N-Entpd1tm1b(EUCOMM)Wtsi/Ieg |
| Alternative name | EPD0156_1_B01 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Entpd1tm1b(EUCOMM)Wtsi |
| Gene/Transgene symbol | Entpd1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0156_1_B01. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sor |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTacUSA |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive spastic paraplegia type 64 / Orphanet_401810
IMPC phenotypes (gene matching)
- decreased grip strength / IMPC
- decreased circulating glycerol level / IMPC
- increased circulating chloride level / IMPC
- decreased total body fat amount / IMPC
- increased mean corpuscular hemoglobin concentration / IMPC
- increased bone mineral content / IMPC
- thrombocytopenia / IMPC
- tremors / IMPC
- increased IgE level / IMPC
- increased circulating sodium level / IMPC
- abnormal bone mineralization / IMPC
- decreased circulating free fatty acids level / IMPC
MGI phenotypes (gene matching)
- abnormal blood flow velocity / MGI
- impaired smooth muscle contractility / MGI
- abnormal brain morphology / MGI
- abnormal neutrophil physiology / MGI
- increased susceptibility to ischemic brain injury / MGI
- cardiac fibrosis / MGI
- thrombocytopenia / MGI
- liver fibrosis / MGI
- renal fibrosis / MGI
- abnormal vascular endothelial cell physiology / MGI
- abnormal muscle electrophysiology / MGI
- homeostasis/metabolism phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal neurotransmitter secretion / MGI
- abnormal synaptic norepinephrine release / MGI
- abnormal platelet physiology / MGI
- increased bleeding time / MGI
- pulmonary fibrosis / MGI
- increased cerebral infarction size / MGI
- increased neurotransmitter release / MGI
- decreased platelet aggregation / MGI
- spleen fibrosis / MGI