C57BL/6NTac-Cpt2tm1a(KOMP)Wtsi/WtsiBiat

Status

Available to order

EMMA IDEM:08052
Citation informationRRID:IMSR_EM:08052 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Cpt2tm1a(KOMP)Wtsi/WtsiBiat
Alternative nameEPD0030_2_H06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCpt2tm1a(KOMP)Wtsi
Gene/Transgene symbolCpt2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0030_2_H06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Carnitine palmitoyl transferase II deficiency, neonatal form / Orphanet_228308
    • Carnitine palmitoyl transferase II deficiency, severe infantile form / Orphanet_228305
    • Carnitine palmitoyl transferase II deficiency, myopathic form / Orphanet_228302
IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • increased circulating phosphate level / IMPC
  • abnormal vertebrae morphology / IMPC
MGI phenotypes (gene matching)
  • no abnormal phenotype detected / MGI
  • abnormal trachea morphology / MGI
  • abnormal Mullerian duct morphology / MGI
  • hemopericardium / MGI
  • abnormal hepatic vein morphology / MGI
  • abnormal Mullerian duct topology / MGI
  • blood in lymph vessels / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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